CD26
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Official Full Name
Cluster of Differentiation 26 -
Overview
Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. -
Synonyms
ADA-binding protein;ADABP;ADCP 2;ADCP-2;ADCP2;Adenosine deaminase complexing protein 2;CD 26;CD26;CD26 antigen 3;Dipeptidyl peptidase 4;Dipeptidyl peptidase 4 soluble form;Dipeptidyl peptidase IV;Dipeptidyl peptidase IV membrane form;Dipeptidyl peptidase IV soluble form;Dipeptidylpeptidase 4;Dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2);Dipeptidylpeptidase IV;DPP 4;DPP IV;DPP IV estoenzyme;DPP4;DPP4_HUMAN;DPPIV;Intestinal dipeptidyl peptidase;T cell activation antigen CD26;T-cell activation antigen CD26;TP 103;TP103;cluster of differentiation 26
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Involved Pathway
CD26 involved in several pathways and played different roles in them. We selected most pathways CD26 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CD26 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
CD26 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by CD26 itself. We selected most functions CD26 had, and list some proteins which have the same functions with CD26. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
CD26 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD26 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD26.
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References
- Ohnuma, K; Saito, T; et al. Comparison of Two Commercial ELISAs against an In-House ELISA for Measuring Soluble CD26 in Human Serum. JOURNAL OF CLINICAL LABORATORY ANALYSIS 29:106-111(2015).
- Fossum, E; Grodeland, G; et al. Vaccine molecules targeting Xcr1 on cross-presenting DCs induce protective CD8(+) T-cell responses against influenza virus. EUROPEAN JOURNAL OF IMMUNOLOGY 45:624-635(2015).
