CCT3
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Official Full Name
chaperonin containing TCP1, subunit 3 (gamma) -
Overview
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants have been characterized for this gene. In addition, a pseudogene of this gene has been found on chromosome 8. -
Synonyms
CCT3;chaperonin containing TCP1, subunit 3 (gamma);TRIC5;T-complex protein 1 subunit gamma;Cctg;CCT 3;CCT gamma;Chaperonin containing TCP1 subunit 3 (gamma);Chaperonin containing TCP1 subunit 3;hTRiC5;PIG48;T complex protein 1 gamma subunit;T complex protein 1 subunit gamma;TCP 1 gamma;TCP1 (t complex 1) ring complex polypeptide 5;T-complex protein 1, gamma subunit;TCP1 (t-complex-1) ring complex, polypeptide 5;CCT-gamma;TCP-1-gamma
Recombinant Proteins
- Human
- Rat
- Mouse
- Zebrafish
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- Mammalian cells
- In Vitro Cell Free System
- HEK293T
- GST
- His
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
CCT3 involved in several pathways and played different roles in them. We selected most pathways CCT3 participated on our site, such as Assembly of the primary cilium,Association of TriC/CCT with target proteins during biosynthesis,BBSome-mediated cargo-targeting to cilium, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCT3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | CCT4,TUBA1B,PFDN2,TUBA3D,VBP1,CCT5,CCT8,PFDN1,PFDN6,TUBB4A |
| Association of TriC/CCT with target proteins during biosynthesis | KIFC3,FBXL5,CCT5,CCT2,FBXW2,CCT4,CCT7,FBXW9,NOP56,FBXW5 |
| Assembly of the primary cilium | EXOC8,ACTR1A,IFT122,CEP89,WDR19,TTC30B,CETN2,DYNLRB1,ARL3,AKAP9 |
| Chaperonin-mediated protein folding | CCT6A,FBXL5,PFDN4,TUBB4B,FKBP9,NOP56,PFDN5,CCT8,KIFC3,FBXW9 |
| Formation of tubulin folding intermediates by CCT/TriC | TUBB4A,TCP1,CCT8,TUBA1B,CCT6A,TUBA3D,CCT4,CCT2,CCT5,TUBB4B |
| BBSome-mediated cargo-targeting to cilium | BBS2,BBS4,TCP1,CCT5,CCT4,BBS7,BBS9,LZTFL1,MKKS,RAB3IP |
| Cargo trafficking to the periciliary membrane | EXOC1,PKD1,BBS12,BBS1,BBS2,EXOC8,BBS10,CNGA2,ARL13B,RAB3IP |
| Folding of actin by CCT/TriC | CCT2,CCT4,CCT6A,TCP1,CCT7,CCT8,CCT5 |
Protein Function
CCT3 has several biochemical functions, for example, ATP binding,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCT3 itself. We selected most functions CCT3 had, and list some proteins which have the same functions with CCT3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| unfolded protein binding | CCT2,TBCA,DNAJA2,PFDN1,NDUFAF1,HSPA2,AIPL1,TRAP1,HSPA5,CCT8 |
| poly(A) RNA binding | ERAL1,KHDRBS1,PES1,PPIE,RTF1,EIF3D,PRPF8,YTHDF2,ARL6IP4,CSTF2T |
| protein binding | RHOV,PAX2,AGGF1,PSEN1,LRRC75A-AS1,KDM6B,VSNL1,AKAP12,EGR1,CRKL |
| ATP binding | RBKS,TNIKA,UCK2,DDX6,PIP5K2,DNAH6,ACSBG2,NEK11,CDK6,ATP1A3B |
Interacting Protein
CCT3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCT3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCT3.
PPP4C;PPP2CB;PPP2CA;STRN3;ILK;WRAP53
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