CCT2
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Official Full Name
chaperonin containing TCP1, subunit 2 (beta) -
Overview
CCT2 is one of eight largely unrelated subunit proteins found in a protein chaperone complex known as the chaperonin-containing TCP-1 (CCT) or TRiC complex. The CCT complex is an abundanct cytoslic component that is credited with helping newly synthesized -
Synonyms
CCT2;chaperonin containing TCP1, subunit 2 (beta);T-complex protein 1 subunit beta;Cctb;T-complex protein 1, beta subunit;chaperonin containing t-complex polypeptide 1, subunit 2;chaperonin containing t-complex polypeptide 1, beta subunit;99D
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Chicken
- Mouse
- Cynomolgus
- Rhesus macaque
- Wheat Germ
- Mammalian Cell
- E.coli
- HEK293
- Yeast
- In Vitro Cell Free System
- HEK293T
- GST
- His
- Non
- His&Fc&Avi
- His&SUMO
- Myc&DDK
Involved Pathway
CCT2 involved in several pathways and played different roles in them. We selected most pathways CCT2 participated on our site, such as Assembly of the primary cilium,Association of TriC/CCT with target proteins during biosynthesis,BBSome-mediated cargo-targeting to cilium, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| BBSome-mediated cargo-targeting to cilium | BBS4,PROL1,MKKS,RAB3IP,CCT5,BBS1,CCT4,LZTFL1,SETD6,TTC8 |
| Formation of tubulin folding intermediates by CCT/TriC | TUBA3D,TCP1,TUBA1B,TUBB4B,CCT8,CCT4,TUBB4A,CCT3,CCT7,CCT6A |
| Assembly of the primary cilium | BBS10,TCTEX1D1,DCTN2,ODF2B,PLK4,TRIP11,LZTFL1,ARF4A,IFT22,CLASP1 |
| Cargo trafficking to the periciliary membrane | NPHP3,BBS1,BBS9,ARL3,SSTR3,PKD1,EXOC3,BBS12,SETD6,PKD2 |
| Folding of actin by CCT/TriC | CCT3,CCT5,CCT6A,CCT7,CCT8,TCP1,CCT4 |
| Association of TriC/CCT with target proteins during biosynthesis | CCT8,CCT6A,NOP56,FBXL5,FBXW9,CCT3,CCT5,FBXW2,CCT7,FBXW5 |
| Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | TUBB4A,TUBA3D,CCT8,CCT5,PFDN2,CCT7,CCT4,TUBB4B,VBP1,PFDN4 |
| Chaperonin-mediated protein folding | CCT6A,TUBB4B,KIFC3,FKBP9,CCT3,FBXW4,PFDN2,CCT8,NOP56,VBP1 |
Protein Function
CCT2 has several biochemical functions, for example, ATP binding,protein binding,ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCT2 itself. We selected most functions CCT2 had, and list some proteins which have the same functions with CCT2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin protein ligase binding | C10orf46,HSPA1L,UBE2N,FZD5,TNFRSF14,CDC34B,SCAMP3,ATP6V0C,RNF20,TNFRSF1B |
| ATP binding | UBE2D2A,MAPK12,KIF3C,OLA1,SIK2A,PSMC6,CKM,ROCK2A,ATP6V1B2,ATP6AP1 |
| protein binding | C20orf195,LRP5,COASY,RAB17,ASAP1,MAP2K3,SPATA22,POU4F1,CRMP1,RPS18 |
| unfolded protein binding | HSPA8,CRYABA,TOMM20,AHSP,HSP90AA1.2,DNAJB8,PPIB,CCDC102A,CDC37,DNAJA1 |
Interacting Protein
CCT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCT2.
PPP2CA;PPP4C;PPP2CB;STRN3;BBS7;WRAP53
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