CCRL2
-
Official Full Name
chemokine (C-C motif) receptor-like 2 -
Overview
This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located. -
Synonyms
CCRL2;chemokine (C-C motif) receptor-like 2;C-C chemokine receptor-like 2;CKRX;CRAM A;CRAM B;HCR;Chemokine (C-C motif) receptor like 2;Chemokine receptor CCR11;Chemokine receptor X;CRAMA;CRAMB;FLJ55815;MGC116710;MGC34104;Putative MCP 1 chemokine receptor;OTTHUMP00000209758;OTTHUMP00000209759;putative MCP-1 chemokine receptor;CRAM;CRAM-A;CRAM-B
Recombinant Proteins
- Human
- Mouse
- Bovine
- Sus scrofa (Pig)
- Mus musculus
- Macaca mulatta
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- E.coli
- Non
- GST
- His
- Flag
- His&Fc&Avi
Involved Pathway
CCRL2 involved in several pathways and played different roles in them. We selected most pathways CCRL2 participated on our site, such as Chemokine receptors bind chemokines,Class A/1 (Rhodopsin-like receptors),GPCR ligand binding, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCRL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GPCRs, Class A Rhodopsin-like | FPR-RS4,GPR68,OPN1MW2,GPR20,NMUR1,CHRM4,SSTR2,DRD4,ADORA1,CMKLR1 |
| Signal Transduction | EVC2,RSPO3,PRDM4,PTH2,DRAP1,PDK3,GAL,BCO2A,FOXH1,RNF31 |
| Chemokine receptors bind chemokines | CCR9,AMCF-II,CCR5,CCR3,CCBP2,CCL19A.2,CCR8,CCL35.1,CCR1,CCL27 |
| Peptide ligand-binding receptors | TAC1,NPFF,HEBP1,NPB,INSL5,AMCF-II,NTS,PRLH,TAC2,NMBB |
| GPCR ligand binding | FFAR3,ADORA1,ADRA2B,RLN3,GPR37B,HRH3,ADM2A,NPS,AGTR2,NPB |
| Signaling by GPCR | GPR37L1,RGS10,GNA13B,OXGR1A.1,MLN,SCT,NMBA,PENK,SST1.1,CCL19A.2 |
| Class A/1 (Rhodopsin-like receptors) | UTS2,CHRM2,ADRa1A,OPN1SW,GAL,HCRT,OPN1LW1,LPAR1,NMUR1,CCR5 |
Protein Function
CCRL2 has several biochemical functions, for example, CCR chemokine receptor binding,chemokine receptor activity,chemokine receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCRL2 itself. We selected most functions CCRL2 had, and list some proteins which have the same functions with CCRL2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| CCR chemokine receptor binding | CCL38A.5,XCL1,CCL33.3,XCL2,CCL21,CXCL32B.1,CCL44,CCL34B.1,CCL34A.4,CCL19B |
| chemokine receptor binding | CCL25,XCL1,CXCL12,S100A14,CCL21B,CCL19,CCL5,Ccl21a,Ccl21c,CCL21 |
| chemokine receptor activity | CCR5,RGRB,CCR12A,CMKLR1,RGRA,ACKR4,CXCR4A,ACKR3B,CXCR3,GPR17 |
Interacting Protein
CCRL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCRL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCRL2.
Resources
Research Area
Inflammatory/Monocyte-derived Dendritic CellsB Cell Chemotaxis, Migration, and Adhesion
Th17 Cells
Th22 Cells
Dendritic Cell Adhesion and Migration
Related Services
Related Products
References
