CCNT1

  • Official Full Name

    cyclin T1

  • Overview

    The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin tightly associates with CDK9 kinase, and was found to be a major subunit of the transcription elongation factor p-TEFb. The kinase complex containing this cyclin and the elongation factor can interact with, and act as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and was shown to be both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner were also found to be involved in the phosphorylation and regulation of the carboxy-terminal domain (CTD) of the largest RNA polymerase II subunit.

  • Synonyms

    CCNT1;cyclin T1;HIVE1, human immunodeficiency virus type 1 (HIV 1) expression (elevated) 1;cyclin-T1;CCNT;CYCT1;cyclin-T;cyclin T1b;cyclin C-related protein;CDK9-associated C-type protein;Human immunodeficiency virus-1 expression;subunit of po

Recombinant Proteins

  • Human
  • Mouse
  • Zebrafish
  • Wheat Germ
  • Mammalian Cell
  • HEK293
  • In Vitro Cell Free System
  • E.coli
  • GST
  • His
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
CCNT1-0680H Recombinant Human CCNT1 Protein, GST-Tagged Wheat Germ Human GST
CCNT1-3005M Recombinant Mouse CCNT1 Protein Mammalian Cell Mouse His
CCNT1-8168Z Recombinant Zebrafish CCNT1 Mammalian Cell Zebrafish His
CCNT1-308HCL Recombinant Human CCNT1 cell lysate Human Non
CCNT1-1415M Recombinant Mouse CCNT1 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
CCNT1-1415M-B Recombinant Mouse CCNT1 Protein Pre-coupled Magnetic Beads HEK293 Mouse
CCNT1-2994HF Recombinant Full Length Human CCNT1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 726 amino acids
CCNT1-5454H Recombinant Human CCNT1 protein, His-tagged E.coli Human His 1-726aa

    Involved Pathway

    CCNT1 involved in several pathways and played different roles in them. We selected most pathways CCNT1 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCNT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Transcriptional misregulation in cancer NFKBIZ,RARA,GRIA3,WHSC1,ZBTB17,JMJD1C,RXRG,ETV1,MLL1,PFTK1

    Protein Function

    CCNT1 has several biochemical functions, for example, DNA binding,chromatin binding,cyclin-dependent protein serine/threonine kinase regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCNT1 itself. We selected most functions CCNT1 had, and list some proteins which have the same functions with CCNT1. You can find most of the proteins on our site.

    Function Related Protein
    snRNA binding RBPMS,SNRNP35,HEXIM2,CDK9,NCBP2,HEXIM1
    transcription regulatory region DNA binding KLF1,HDAC1,JUN,FOXA2,PAX8,TCF7L1A,TBL1X,DLX5,PRDM5,NCOR1
    DNA binding H1M,SP110,REPIN1,PROX1,SAP30L,NOSTRIN,RBM6,GCM1,ZNF530,NKX2
    protein binding PHB2,TRAPPC4,SAV1,SP100,GAS6,HIP1,CST3,TBL1XR1,ZMAT2,C14orf93
    cyclin-dependent protein serine/threonine kinase regulator activity CCNE2,CDK4,CCNL1A,CCND1,FAM58A,CCNE1,CCNL2,CCNL1,CKS1B,CCNL1B
    chromatin binding L3MBTL1,RERE,KDM1A,HIF1AB,SAFB,LHX2,TOX,PBX2,CSNK2B,PHF8

    Interacting Protein

    CCNT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCNT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCNT1.

    CDK9;AFF4;HEXIM1

    Resources

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