CCNF
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Official Full Name
cyclin F -
Overview
This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified. -
Synonyms
CCNF;cyclin F;cyclin-F;FBX1;FBXO1;F box only protein 1;G2 mitotic specific cyclin F;OTTHUMP00000159081;F-box only protein 1;G2/mitotic-specific cyclin-F
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Mouse
- Rhesus macaque
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
CCNF involved in several pathways and played different roles in them. We selected most pathways CCNF participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CCNF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
CCNF has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCNF itself. We selected most functions CCNF had, and list some proteins which have the same functions with CCNF. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | VEGFAB,HIST1H3C,DCP2,CA2,LSAMP,GLRA1,SURF1,MSX2,TMX3,LGALS6 |
Interacting Protein
CCNF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCNF here. Most of them are supplied by our site. Hope this information will be useful for your research of CCNF.
CCP110;RRM2;SKP1
Resources
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References
- Wu, BB; Yuan, TY; et al. Construction, Expression and Characterization of a Single Chain Variable Fragment Antibody Against Human Myostatin. PROTEIN AND PEPTIDE LETTERS 21:45-51(2014).
- Yu, XM; Wang, L; et al. Wnt5a inhibits hypoxia-induced pulmonary arterial smooth muscle cell proliferation by downregulation of beta-catenin. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 304:L103-L111(2013).
