CCNE2
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Official Full Name
cyclin E2 -
Overview
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells. -
Synonyms
CCNE2;cyclin E2;G1/S-specific cyclin-E2;CYCE2
Recombinant Proteins
- Human
- Chicken
- Zebrafish
- E.coli
- Wheat Germ
- Insect Cell
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- GST
- His
- T7
- Non
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CCNE2-10864H | Recombinant Human CCNE2, GST-tagged | E.coli | Human | GST | 1-374a.a. | |
| CCNE2-2774H | Recombinant Human CCNE2 protein, His-tagged | E.coli | Human | His | 1-141 aa | |
| CCNE2-3047H | Recombinant Human CCNE2 protein, His-tagged | E.coli | Human | His | 1-374 aa | |
| CCNE2-0667H | Recombinant Human CCNE2 Protein, GST-Tagged | Wheat Germ | Human | GST |
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| CCNE2-180H | Recombinant Human CCNE2 protein, GST-tagged | Insect Cell | Human | GST |
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| CCNE2-2634C | Recombinant Chicken CCNE2 | Mammalian Cell | Chicken | His |
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| CCNE2-2918H | Recombinant Human Cyclin E2, T7-tagged | E.coli | Human | T7 |
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| CCNE2-307Z | Recombinant Zebrafish CCNE2 | Mammalian Cell | Zebrafish | His |
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| CCNE2-7709HCL | Recombinant Human CCNE2 293 Cell Lysate | HEK293 | Human | Non |
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| CCNE2-2972HF | Recombinant Full Length Human CCNE2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 374 amino acids |
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Involved Pathway
CCNE2 involved in several pathways and played different roles in them. We selected most pathways CCNE2 participated on our site, such as Cell cycle,Oocyte meiosis,p signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCNE2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Measles | DOK1,NFKBIA,TP53,IFNG,CCND2,IL2RA,OAS2,IFNA13,IRF3,OAS1B |
| PIK-Akt signaling pathway | IFNB1,RAF1,PIK3R5,Reln,RPTOR,ITGA1,IL6,PRLR,GSK3B,IL3 |
| Cell cycle | CENPC1,SYNE1,CCNA2,CDC14A,SMC4,KIF18A,APITD1,ERCC6L,TUBGCP5,CEP135 |
| Prostate Cancer | ATF4,CASP9,PIK3CD,FOXA1,HRAS,ERBB2,PDGFRB,ARID1A,PIK3CB,NKX3 |
| Pathways in cancer | BIRC8,FGF22,PRKCB,FOS,FLT3LG,TPR,GNAQ,PLCB3,LAMA1,Shh |
| Viral carcinogenesis | CCNA2,Casp3,UBR4,MAPKAPK2,TRAF3,SND1,CCNE1,PRKACG,HIST1H2BL,POLB |
| p signaling pathway | CASP8,CD82A,SERPINB5,GADD45AA,PTENA,TP53AIP1,RPRMA,BAI1,TSC2,ZMAT3 |
| MicroRNAs in cancer | RECK,NOTCH2,BMF,PLCG1,HRAS,SOCS1,DDIT4,VEGFA,NOTCH4,CCNG1 |
| Hepatitis B | IFNA2,CREB5,IRF7,IKBKE,CYCS,AKT2,CASP8,STAT5A,MAVS,CCNA1 |
Protein Function
CCNE2 has several biochemical functions, for example, cyclin-dependent protein serine/threonine kinase regulator activity,protein binding,protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCNE2 itself. We selected most functions CCNE2 had, and list some proteins which have the same functions with CCNE2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase binding | CD8A,CCNE1,SLC12A4,EEF1A1,PPME1,ADRA2A,MAPK8IP2,SPRED1,MAP3K5,DLG1 |
| cyclin-dependent protein serine/threonine kinase regulator activity | CKS2,FAM58A,CCNE1,CCNT2A,CCNY,CCNL1B,PSTPIP2,CCNL1,CCNT2,CCNL2 |
| protein binding | C2orf57,RPL15,RABGEF1,NPY1R,FAM72A,SIRT3,EDN1,IKZF1,JRK,POLD3 |
Interacting Protein
CCNE2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCNE2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCNE2.
CDK2;CDKN1A;CDKN1B;RBL2;ORC3;E7;CDKN1C;CDK3
CCNE2 Related Signal Pathway
Resources
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References
- Du, HY; Jie, LG; et al. A Monoclonal Antibody Against a Potential Cancer Biomarker, Human Ubiquitin-Conjugating Enzyme E2. HYBRIDOMA 31:196-202(2012).
- Nair, BC; Nair, SS; et al. Cyclin-Dependent Kinase-Mediated Phosphorylation Plays a Critical Role in the Oncogenic Functions of PELP1. CANCER RESEARCH 70:7166-7175(2010).
