CCNB3
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Official Full Name
cyclin B3 -
Overview
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as positive regulators of cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle. Different cyclins exhibit distinct expression and degradation patterns, which contribute to the temporal coordination of each mitotic event. Studies of similar genes in chicken and drosophila suggest that this cyclin may associate with CDC2 and CDK2 kinases, and may be required for proper spindle reorganization and restoration of the interphase nucleus. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. -
Synonyms
CCNB3;cyclin B3;G2/mitotic-specific cyclin-B3;CCNB 3;CYCB3;G2/mitotic specific cyclin B3
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CCNB3-0656H | Recombinant Human CCNB3 Protein, GST-Tagged | Wheat Germ | Human | GST |
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| CCNB3-4561Z | Recombinant Zebrafish CCNB3 | Mammalian Cell | Zebrafish | His |
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| CCNB3-6792C | Recombinant Chicken CCNB3 | Mammalian Cell | Chicken | His |
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| CCNB3-304HCL | Recombinant Human CCNB3 cell lysate | Human | Non |
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Involved Pathway
CCNB3 involved in several pathways and played different roles in them. We selected most pathways CCNB3 participated on our site, such as FoxO signaling pathway,Cell cycle,p signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCNB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| FoxO signaling pathway | SMAD4,GRB2A,RAF1A,PIK3CG,MAPK8B,SGK2B,EGFRA,CCND1,PTENA,KRAS |
| p signaling pathway | SHISA5,CCND3,RPRMA,CDK1,GADD45AB,ZMAT3,TSC2,CASP9,SERPINB5,PIDD1 |
| Cell cycle | INCENP,GADD45BB,SKP2,MYCA,WAPAL,NUP35,MIS18BP1,TP53BP1,UBE2V2,B9D2 |
| Progesterone-mediated oocyte maturation | ADCY2B,RPS6KA1,CPEB1A,CCNA1,GNAI2A,GNAI3,PRKACAA,INS,AKT1,ANAPC2 |
Protein Function
CCNB3 has several biochemical functions, for example, protein binding,protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCNB3 itself. We selected most functions CCNB3 had, and list some proteins which have the same functions with CCNB3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase binding | STX1B,RPS3,BAD,HSP90AB1,RAB11FIP2,SLC12A5,CAMK2N2,PGAM1,EEF1A1,AP2A2 |
| protein binding | MUC7,PRDX4,DCDC2,EEF1B2,UNG,FOXK2,IL1R1,IL11,EIF2B3,HLTF |
Interacting Protein
CCNB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCNB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCNB3.
Plk4;CDK2;p27958-pro_0000037566
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References
- Kim, N; Xiao, R; et al. Abnormal Sperm Development in pcd (3J)-/- Mice: the Importance of Agtpbp1 in Spermatogenesis. MOLECULES AND CELLS 31:39-48(2011).
- Ozaki, Y; Saito, K; et al. Evaluation of Sycp3, Plzf and Cyclin B3 expression and suitability as spermatogonia and spermatocyte markers in zebrafish. GENE EXPRESSION PATTERNS 11:309-315(2011).
