CCDC88A
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Official Full Name
coiled-coil domain containing 88A -
Overview
This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. -
Synonyms
AKT iphosphorylation enhancer;Akt phosphorylation enhancer;APE;Ccdc88a;Coiled coil domain containing protein 88A;Coiled-coil domain-containing protein 88A;FLJ10392;G alpha interacting vesicle associated protein;G alpha-interacting vesicle-associated protein;Galpha interacting vesicle associated protein;Girders of actin filament;Girdin;GIV;GRDN;GRDN_HUMAN;HkRP1;Hook related protein 1;Hook-related protein 1;KIAA1212
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CCDC88A-2940M | Recombinant Mouse CCDC88A Protein | Mammalian Cell | Mouse | His |
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| CCDC88A-1376M | Recombinant Mouse CCDC88A Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| CCDC88A-1376M-B | Recombinant Mouse CCDC88A Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| CCDC88A-627H | Recombinant Human CCDC88A protein, His-tagged | E.coli | Human | His | 1713-1823aa |
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Involved Pathway
CCDC88A involved in several pathways and played different roles in them. We selected most pathways CCDC88A participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CCDC88A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
CCDC88A has several biochemical functions, for example, actin binding,microtubule binding,phosphatidylinositol binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCDC88A itself. We selected most functions CCDC88A had, and list some proteins which have the same functions with CCDC88A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| actin binding | SYNPO2L,INPPL1B,WASLA,TPM3,MYO1C,DIAPH1,IPP,SHANK3,LCP1,INO80 |
| microtubule binding | CDK5RAP2,KIFC2,KIF25,KCNH2A,CETN1,REEP4,MTAP6,KRIT1,FTCD,CAMSAP2A |
| protein binding | SNX5,ROCK2A,ELMO2,OSBP2,DNAJA4,LEPROT,GLI2,PLEK,BCOR,TESC |
| protein kinase B binding | PDE3B,RARA,BAD,TRAF6,APPL1,BCL10,ANKRD2,CDC37,PINK1 |
| protein homodimerization activity | GDF7,PEX11B,HHEX,TMEM192,EVLA,NOD1,S100A11,ZNF174,PVRL1,ZFP423 |
| phosphatidylinositol binding | PASK,SNX27B,SNX17,HIP1R,SNX10A,TULP3,SNX1,SNX19A,SNX10B,TULP2 |
Interacting Protein
CCDC88A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCDC88A here. Most of them are supplied by our site. Hope this information will be useful for your research of CCDC88A.
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