CBLL1
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Official Full Name
Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1 -
Overview
This gene encodes an E3 ubiquitin-ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes. The encoded protein contains a RING-finger domain and is also thought to have a role in control of cell proliferation. A related pseudogene has been identified on chromosome X. Alternative splicing results in a non-coding transcript variant. -
Synonyms
CBLL1;Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1;E3 ubiquitin-protein ligase Hakai;Casitas B lineage lymphoma like;FLJ23109;HAKAI;RNF188;c-Cbl-like protein 1;Casitas B-lineage lymphoma transforming sequence-like protein 1;Casitas B-lineage lymphoma-like 1;Casitas B-lineage lymphoma-transforming sequence-like protein 1;HAKAI_HUMAN;RING finger protein 188;OTTHUMP00000206719;OTTHUMP00000206720;OTTHUMP00000206722;OTTHUMP00000206724;E-cadherin binding protein E7
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Mouse
- Rhesus macaque
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CBLL1-10758H | Recombinant Human CBLL1, GST-tagged | E.coli | Human | GST | 4-240a.a. | |
| CBLL1-0462H | Recombinant Human CBLL1 Protein, GST-Tagged | Wheat Germ | Human | GST |
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| CBLL1-11292Z | Recombinant Zebrafish CBLL1 | Mammalian Cell | Zebrafish | His |
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| CBLL1-1773C | Recombinant Chicken CBLL1 | Mammalian Cell | Chicken | His |
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| CBLL1-2781M | Recombinant Mouse CBLL1 Protein | Mammalian Cell | Mouse | His |
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| CBLL1-639R | Recombinant Rhesus monkey CBLL1 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| CBLL1-7813HCL | Recombinant Human CBLL1 293 Cell Lysate | HEK293 | Human | Non |
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| CBLL1-1264M | Recombinant Mouse CBLL1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| CBLL1-1264M-B | Recombinant Mouse CBLL1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| CBLL1-2770HF | Recombinant Full Length Human CBLL1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 491 amino acids |
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| CBLL1-467R | Recombinant Rhesus Macaque CBLL1 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| CBLL1-467R-B | Recombinant Rhesus Macaque CBLL1 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
CBLL1 involved in several pathways and played different roles in them. We selected most pathways CBLL1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CBLL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
CBLL1 has several biochemical functions, for example, identical protein binding,ligase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CBLL1 itself. We selected most functions CBLL1 had, and list some proteins which have the same functions with CBLL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | PDCD6,FHOD1,ZNF703,PUF60,GM5077,MNS1,GCG,FGFR1,GRIK5,TRIP10 |
| ligase activity | SYVN1,RBCK1,RNF144AA,TRIM21,BRCA1,HLTF,MARCH2,LNX1,RBBP6,RNF13 |
| protein binding | PPP1R15B,RAD21,LRP2BP,TIPIN,RTN2,LOX,GM5506,PCNA,KRT6B,LATS2 |
| zinc ion binding | ZFP385C,LIMK1A,ZNFL1,DPYS,MARCH9,ZFP259,ZCCHC16,MMP14A,LIMA1,RNF11A |
| ubiquitin-protein transferase activity | HUWE1,RFWD3,RNF220,WWP1,UBE2W,TNFAIP3,TRIM62,RNF25,TRIM69,CMTM2A |
| ubiquitin protein ligase activity | MED23,TRIM2,FBXO6,RNF121,RBX1,RNF175,MED17,RNF146,NEURL3,ZSWIM2 |
Interacting Protein
CBLL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CBLL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CBLL1.
CDH1;YWHAZ;q81kb5_bacan;SRC;KIF26B
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References
- Cao, MH; Zheng, HY; et al. Upregulation of CBLL1 in rat brain cortex after lipopolysaccharide treated. JOURNAL OF MOLECULAR HISTOLOGY 44:135-145(2013).
- Oshida, K; Maeda, A; et al. Novel gene markers of immunosuppressive chemicals in mouse lymph node assay. TOXICOLOGY LETTERS 205:79-85(2011).
