CASP5
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Official Full Name
caspase 5, apoptosis-related cysteine peptidase -
Overview
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. -
Synonyms
Apoptosis related cysteine protease;apoptosis-related cysteine protease;CASP5;ICE(rel)III;ICERELIII;ICH 3;ICH 3 protease;ICH3;TY;TY Protease;caspase-5;CASP-5;OTTHUMP00000045729;OTTHUMP00000209889;OTTHUMP00000231914;OTTHUMP00000231915;caspase 5, apoptosis-related cysteine peptidase;MGC141966;EC 3.4.22.58;EC 3.4.22
Recombinant Proteins
- Human
- Arabidopsis thaliana
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- Yeast
- GST
- Non
- His
- His&T7
- His&Fc&Avi
- His&SUMO
Involved Pathway
CASP5 involved in several pathways and played different roles in them. We selected most pathways CASP5 participated on our site, such as NOD-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CASP5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| NOD-like receptor signaling pathway | CXCL2,RELA,MAPK12B,MAPK3,IKBKB,MAPK9,PYDC1,MAP3K7,IKBKG,SGUT1 |
Protein Function
CASP5 has several biochemical functions, for example, NOT cysteine-type endopeptidase activity involved in execution phase of apoptosis,cysteine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CASP5 itself. We selected most functions CASP5 had, and list some proteins which have the same functions with CASP5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cysteine-type peptidase activity | USP43,ATG4B,CTSL1,CAPN2L,USPL1,SENP3A,BLMH,CASP3A,CTSBA,OTUD4 |
| NOT cysteine-type endopeptidase activity involved in execution phase of apoptosis | CASP4,CASPA,CASP1,CASPBL,CASPB,CASP12,PSD |
Interacting Protein
CASP5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CASP5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CASP5.
NLRP1
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