CASP12
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Official Full Name
caspase 12 (gene/pseudogene) -
Overview
The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation. -
Synonyms
CASP12;UNQ9415;Apoptosis related cysteine protease;CASP 12;CASP-12;CASP12P1;Caspase 12 pseudogene 1;Caspase12;CASPC_HUMAN;Inactive caspase-12;inactive caspase-12-like;EC 3.4.22
Recombinant Proteins
- Rat
- Mouse
- Rhesus macaque
- Human
- Mammalian Cells
- E.coli
- HEK293
- His
- GST
- T7
- Avi
- Fc
- SUMO
Involved Pathway
CASP12 involved in several pathways and played different roles in them. We selected most pathways CASP12 participated on our site, such as Alzheimers disease,Amyotrophic lateral sclerosis (ALS),Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CASP12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hepatitis B | PCNA,EGR2,STAT1,MAVS,ELK1,AKT1,EGR3,IFNA17,RB1,IFNA8 |
| Alzheimers disease | PLCB2,Atp5g2,CALM4,APH1B,GRIN2C,ATP5G1,FAS,ATP5D,ATP5F1,NDUFA7 |
| Amyotrophic lateral sclerosis (ALS) | NEFM,GRIA2,PPP3R2,CCS,MAP3K5,DAXX,NEFL,TOMM40,MAPK12,BID |
| Apoptosis | DYNLL2,DERL3,ATM,IRAK1,GAS2,PIK3CA,PIK3R2,NMT1,IL3,CASP6L1 |
| Corticotropin-releasing hormone | CYP11A1,JUNB,TRIM28,CRHR1,TBX19,CYP21A2,JUND,KRT14,ADRBK2,CRHBP |
| Integrated Pancreatic Cancer Pathway | MAPK4,MYT1,TOP1,CST3,FKBP1B,WRN,GPRC5A,RAPGEF3,TOP2A,RB1CC1 |
| Prion diseases | Hc,CCL5,MAP2K2,MAPK3,PRKACB,C7,C8A,C9,IL6,HSPA1A |
Protein Function
CASP12 has several biochemical functions, for example, NOT cysteine-type endopeptidase activity involved in apoptotic process,NOT cysteine-type endopeptidase activity involved in execution phase of apoptosis. Some of the functions are cooperated with other proteins, some of the functions could acted by CASP12 itself. We selected most functions CASP12 had, and list some proteins which have the same functions with CASP12. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NOT cysteine-type endopeptidase activity involved in execution phase of apoptosis | CASP5,CASP1,CASP4,CASPA,PSD,CASPB,CASPBL |
Interacting Protein
CASP12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CASP12 here. Most of them are supplied by our site. Hope this information will be useful for your research of CASP12.
g3i8r9_crigr
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