CAPNS2
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Official Full Name
calpain, small subunit 2 -
Overview
Both M-calpain and m-calpain are ubiquitously expressed in mammalian cells, and are countered by the endogenous calpain inhibitor, calpastatin. Other calpain family members (calpain-3, calpain-5, calpain-9, etc) have more limited tissue distribution, and perhaps different functions. The calpain family members consist of a common small subunit (Calpain-S1), and a large variable subunit. It is not clear that all calpains form heterodimers with a small subunit, but calpain-S1 is known to form a heterodimer with calpain-1 and also with calpain-2. Calpain S2 was recently discovered, and initial studies indicate that both small subunits may act as chaperonins to help with folding, or accessory proteins to help localize the calpains. Domains in the small subunit include the amino terminal domain-V (a glycine-rich sequence that is removed on activation of calpain, shorter in calpain-S2 than in calpain S1) and domain-VI, the calcium binding, EF hand domain. -
Synonyms
CAPNS2;calpain, small subunit 2;calpain small subunit 2;CSS2;calcium-dependent protease small subunit 2
Recombinant Proteins
- Human
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- HEK293T
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CAPNS2-10708H | Recombinant Human CAPNS2, GST-tagged | E.coli | Human | GST | 5-248a.a. | |
| CAPNS2-0375H | Recombinant Human CAPNS2 Protein, GST-Tagged | Wheat Germ | Human | GST |
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| CAPNS2-2702M | Recombinant Mouse CAPNS2 Protein | Mammalian Cell | Mouse | His |
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| CAPNS2-7858HCL | Recombinant Human CAPNS2 293 Cell Lysate | HEK293 | Human | Non |
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| CAPNS2-1223M | Recombinant Mouse CAPNS2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| CAPNS2-1223M-B | Recombinant Mouse CAPNS2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| Capns2-1954M | Recombinant Mouse Capns2 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| CAPNS2-2831HF | Recombinant Full Length Human CAPNS2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 248 amino acids |
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| CAPNS2-6041H | Recombinant Human CAPNS2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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Involved Pathway
CAPNS2 involved in several pathways and played different roles in them. We selected most pathways CAPNS2 participated on our site, such as Chromatin modifying enzymes,Chromatin organization,HATs acetylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with CAPNS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chromatin organization | MCRS1,KIAA1267,GATAD2AB,MBIP,KAT7,SUZ12,ENY2,KDM7AB,DPY30,PADI4 |
| Chromatin modifying enzymes | KDM4D,MEAF6,SAP18,SUDS3,DPY30,PRMT7,YEATS4,KDM1B,RBBP4,SMARCD3B |
| HATs acetylate histones | MCRS1,ING5B,C3orf75,CCDC101,EP400,MSL1A,MBIP,MSL2,DR1,ZZZ3 |
Protein Function
CAPNS2 has several biochemical functions, for example, chromatin binding,methylated histone binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CAPNS2 itself. We selected most functions CAPNS2 had, and list some proteins which have the same functions with CAPNS2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | RNF185,RNF112,CAR5A,TRIM109,PARK2,TRIM58,SLC25A46,NR2F1,PTPN1,CSRP3 |
| chromatin binding | NFATC2,ZMYND11,MAZ,CHD8,FOSL2,TOP2A,RAN,EP300,EOMES,ATAD2B |
| methylated histone binding | JHDM1D,CHD1,ING2,SPIN1,MSL3,GLYR1,KAT8,ING5,CBX4,RAG2 |
| protein binding | ZNF404,BCS1L,NGB,GBP5,RNF170,ADM,ANTXR2,MST1R,CLSTN1,ANTXR1 |
Interacting Protein
CAPNS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CAPNS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CAPNS2.
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References
- Osugi, K; Suzuki, H; et al. Identification of the P-body component PATL1 as a novel ALG-2-interacting protein by in silico and far-Western screening of proline-rich proteins. JOURNAL OF BIOCHEMISTRY 151:657-666(2012).
- Iguchi-Hashimoto, M; Usui, T; et al. Overexpression of a Minimal Domain of Calpastatin Suppresses IL-6 Production and Th17 Development via Reduced NF-kappa B and Increased STAT5 Signals. PLOS ONE 6:-(2011).
