CAPN10
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Official Full Name
calpain 10 -
Overview
Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene. [provided by RefSeq, Sep 2010] -
Synonyms
CAPN10;calpain 10;CANP10;NIDDM1;calpain-10;calpain-like protease CAPN10;calcium-activated neutral proteinase 10
Recombinant Proteins
- Mouse
- Human
- Cynomolgus
- Mammalian Cell
- Wheat Germ
- E.coli
- HEK293
- In Vitro Cell Free System
- His
- GST
- His&T7
- Non
- His&Fc&Avi
Involved Pathway
CAPN10 involved in several pathways and played different roles in them. We selected most pathways CAPN10 participated on our site, such as Integrin-mediated cell adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with CAPN10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Integrin-mediated cell adhesion | CAPN11,CAPNS1,CAPN3,MAPK6,CAPN3A,MYLK2,TNS1,SEPP1,SEPP1A,CAPN9 |
Protein Function
CAPN10 has several biochemical functions, for example, SNARE binding,calcium-dependent cysteine-type endopeptidase activity,cytoskeletal protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CAPN10 itself. We selected most functions CAPN10 had, and list some proteins which have the same functions with CAPN10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| SNARE binding | TNFAIP2,STX11A,GOSR1,VAMP2,STX5AL,VAMP3,VAMP8,VAMP5,STX1B,STX3A |
| calcium-dependent cysteine-type endopeptidase activity | CAPN3A,CAPN9,CAPNS1B,CAPN3B,PEF1,CAPN2L,CAPN5A,CAPN2B,CAPN12,CAPN11 |
| cytoskeletal protein binding | ANXA2,TOR1A,PDLIM3,PACSIN1,PKD2L1,PACSIN2,EPB41L4B,LDB3,TPM1,FARP2 |
Interacting Protein
CAPN10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CAPN10 here. Most of them are supplied by our site. Hope this information will be useful for your research of CAPN10.
SHD;PSMA7;FLOT1;EFNB1;FANCC
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References
- Fukuta, S; Miyamoto, K; et al. Abundance of calpain and aggrecan-cleavage products of calpain in degenerated human intervertebral discs. OSTEOARTHRITIS AND CARTILAGE 19:1254-1262(2011).
- Reifert, J; Hartung-Cranston, D; et al. Amyloid beta-Mediated Cell Death of Cultured Hippocampal Neurons Reveals Extensive Tau Fragmentation without Increased Full-length Tau Phosphorylation. JOURNAL OF BIOLOGICAL CHEMISTRY 286:20797-20811(2011).
