CALCRL
-
Official Full Name
calcitonin receptor-like -
Overview
CRLR is a receptor for calcitonin gene related peptide type 1. The activity of CRLR is mediated by G proteins which activate adenylyl cyclase. CRLR expression has been reported in brain, lung, blood vessel, liver, and intestinal tract. ESTs have been isolated from B Cell/lung/testis, bone marrow, embryo, lung, and synovium libraries. -
Synonyms
CALCRL;calcitonin receptor-like;CRLR;CGRPR;calcitonin gene-related peptide type 1 receptor;CGRP type 1 receptor;calcitonin receptor-like receptor
Recombinant Proteins
- Human
- Rat
- Chicken
- Xenopus laevis
- Bovine
- Oncorhynchus gorbuscha (Pink salmon) (Salmo gorbuscha)
- Mus musculus
- Paralichthys olivaceus (Bastard halibut) (Hippoglossus olivaceus)
- Sus scrofa (Pig)
- Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
- Wheat Germ
- Mammalian Cell
- E.coli
- HEK293
- In Vitro Cell Free System
- E.coli expression system
- Non
- GST
- His
- His&Flag
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CALCRL-0298H | Recombinant Human CALCRL Protein | Wheat Germ | Human | Non |
|
|
| CALCRL-0299H | Recombinant Human CALCRL Protein, GST-Tagged | Wheat Germ | Human | GST |
|
|
| CALCRL-1090R | Recombinant Rat CALCRL Protein | Mammalian Cell | Rat | His |
|
|
| CALCRL-3992C | Recombinant Chicken CALCRL | Mammalian Cell | Chicken | His |
|
|
| CALCRL-273HCL | Recombinant Human CALCRL cell lysate | Human | Non |
|
||
| CALCRL-1009H | Recombinant Human CALCRL Protein (Glu23-Glu133), N-His tagged | E.coli | Human | His | Glu23-Glu133 |
|
| CALCRL-1053HFL | Recombinant Human CALCRL protein, His&Flag-tagged | HEK293 | Human | His&Flag | 1-461 aa |
|
| CALCRL-3057HF | Recombinant Full Length Human CALCRL Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 352 amino acids |
|
| CALCRL-3058HF | Recombinant Full Length Human CALCRL Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 461 amino acids |
|
| CALCRL-754R | Recombinant Rat CALCRL Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
|
|
| CALCRL-754R-B | Recombinant Rat CALCRL Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
|
||
| RFL1126XF | Recombinant Full Length Xenopus Laevis Calcitonin Gene-Related Peptide Type 1 Receptor(Calcrl) Protein, His-Tagged | E.coli expression system | Xenopus laevis | His | Full L. Full Length of Mature Protein (34-476) |
|
| RFL1595BF | Recombinant Full Length Bovine Calcitonin Gene-Related Peptide Type 1 Receptor(Calcrl) Protein, His-Tagged | E.coli expression system | Bovine | His | Full L. Full Length of Mature Protein (23-462) |
|
| RFL18563OF | Recombinant Full Length Oncorhynchus Gorbuscha Calcitonin Gene-Related Peptide Type 1 Receptor(Calcrl) Protein, His-Tagged | E.coli expression system | Oncorhynchus gorbuscha (Pink salmon) (Salmo gorbuscha) | His | Full L. Full Length of Mature Protein (18-465) |
|
| RFL21621RF | Recombinant Full Length Rat Calcitonin Gene-Related Peptide Type 1 Receptor(Calcrl) Protein, His-Tagged | E.coli expression system | Rat | His | Full L. Full Length of Mature Protein (24-464) |
|
| RFL24122MF | Recombinant Full Length Mouse Calcitonin Gene-Related Peptide Type 1 Receptor(Calcrl) Protein, His-Tagged | E.coli expression system | Mus musculus | His | Full L. Full Length of Mature Protein (23-463) |
|
| RFL25068PF | Recombinant Full Length Paralichthys Olivaceus Calcitonin Gene-Related Peptide Type 1 Receptor(Calcrl) Protein, His-Tagged | E.coli expression system | Paralichthys olivaceus (Bastard halibut) (Hippoglossus olivaceus) | His | Full L. Full Length (21-465) |
|
| RFL32613SF | Recombinant Full Length Pig Calcitonin Gene-Related Peptide Type 1 Receptor(Calcrl) Protein, His-Tagged | E.coli expression system | Sus scrofa (Pig) | His | Full L. Full Length of Mature Protein (23-462) |
|
| RFL32837HF | Recombinant Full Length Human Calcitonin Gene-Related Peptide Type 1 Receptor(Calcrl) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length of Mature Protein (23-461) |
|
| RFL35097XF | Recombinant Full Length Xenopus Tropicalis Calcitonin Gene-Related Peptide Type 1 Receptor(Calcrl) Protein, His-Tagged | E.coli expression system | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | His | Full L. Full Length of Mature Protein (29-472) |
|
Involved Pathway
CALCRL involved in several pathways and played different roles in them. We selected most pathways CALCRL participated on our site, such as Calcitonin-like ligand receptors,Class B/2 (Secretin family receptors),Endothelin, which may be useful for your reference. Also, other proteins which involved in the same pathway with CALCRL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| G alpha (s) signalling events | VIP,CRHR1,ADM2A,CRHB,CRHR2,CRH,ADRB3,PDE10A,INSL3,PTHLH |
| GPCR downstream signaling | GNA13B,OR2AP1,DGKQ,GRP,HEBP1,GAL,PTGDR2,SOUL3,SST1.1,OR56A1 |
| GPCRs, Class B Secretin-like | CRHR2,LPHN1,ADCYAP1R1,ELTD1,EMR2,EMR1,CD97,CRHR1 |
| Class B/2 (Secretin family receptors) | EMR4,ADM2A,GNB5B,ADCYAP1R1,GHRH,RAMP2,SCT,CRHR2,RAMP3,CALCB |
| Calcitonin-like ligand receptors | RAMP3,RAMP1,ADM,RAMP2,ADM2,CALCA,CALCB,ADM2A |
| Endothelin | EDNRA,EDNRB,CNN1,ECE1,MYL1,RAMP1,CALCA,EDN1 |
| GPCR ligand binding | FFAR3,SSTR4,NMS,CCR3,PROKR1A,FPR-RS3,LPAR5A,PENK,OXER1,SCT |
| Neuroactive ligand-receptor interaction | HCRTR2,GRM4,C3AR1,GRIN2A,OPRM1,MC3R,P2RX8,CRHR2,KISS1RB,GHR |
Protein Function
CALCRL has several biochemical functions, for example, G-protein coupled receptor activity,adrenomedullin receptor activity,calcitonin gene-related peptide receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CALCRL itself. We selected most functions CALCRL had, and list some proteins which have the same functions with CALCRL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | HSPA14,RALB,OFCC1,ID3,PPIH,SYN1,DNAI1,CD200R1,NR2F1,SLC22A7 |
| protein transporter activity | AP3S1,C11orf73,XPO6,TIMM10,IPO13,TMCO6,AP1G1,AP1S3A,ZFYVE16,VPS26BL |
| calcitonin receptor activity | RAMP1,CALCRLA,CALCR |
| adrenomedullin receptor activity | GPR182 |
| calcitonin gene-related peptide receptor activity | CRCP |
| G-protein coupled receptor activity | S1PR2,OLFCH1,OXGR1A.1,TAAR11,OPN4.1,PTGER1B,OXGR1A.2,GHRHR2,GPR27,GPR183A |
Interacting Protein
CALCRL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CALCRL here. Most of them are supplied by our site. Hope this information will be useful for your research of CALCRL.
RAMP2;ADM;CALCA;CALCA;RAMP1
Resources
Related Services
Related Products
References
- Vecsei, L; Szok, D; et al. CGRP antagonists and antibodies for the treatment of migraine. EXPERT OPINION ON INVESTIGATIONAL DRUGS 24:31-41(2015).
- Edvinsson, L; Warfvinge, K; et al. CGRP Receptor Antagonism and Migraine Therapy. CURRENT PROTEIN & PEPTIDE SCIENCE 14:386-392(2013).
