CACNG4
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Official Full Name
calcium channel, voltage-dependent, gamma subunit 4 -
Overview
The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type II TARP and a calcium channel gamma subunit. -
Synonyms
CACNG4;calcium channel, voltage-dependent, gamma subunit 4;voltage-dependent calcium channel gamma-4 subunit;MGC11138;MGC24983;Neuronal voltage gated calcium channel gamma 4 subunit;Voltage dependent calcium channel gamma 4 subunit;TARP gamma-4;transmembrane AMPAR regulatory protein gamma-4;neuronal voltage-gated calcium channel gamma-4 subunit
Recombinant Proteins
- Human
- Rat
- Chicken
- Mus musculus
- E.coli
- Mammalian Cell
- HEK293
- E.coli expression system
- GST
- His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CACNG4-10644H | Recombinant Human CACNG4, GST-tagged | E.coli | Human | GST | 200-327a.a. | |
| CACNG4-1073R | Recombinant Rat CACNG4 Protein | Mammalian Cell | Rat | His |
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| CACNG4-5708C | Recombinant Chicken CACNG4 | Mammalian Cell | Chicken | His |
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| CACNG4-737R | Recombinant Rat CACNG4 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| CACNG4-737R-B | Recombinant Rat CACNG4 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| RFL2241RF | Recombinant Full Length Rat Voltage-Dependent Calcium Channel Gamma-4 Subunit(Cacng4) Protein, His-Tagged | E.coli expression system | Rat | His | Full L. Full Length (1-327) |
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| RFL25267HF | Recombinant Full Length Human Voltage-Dependent Calcium Channel Gamma-4 Subunit(Cacng4) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length (1-327) |
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| RFL35361MF | Recombinant Full Length Mouse Voltage-Dependent Calcium Channel Gamma-4 Subunit(Cacng4) Protein, His-Tagged | E.coli expression system | Mus musculus | His | Full L. Full Length (1-327) |
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Involved Pathway
CACNG4 involved in several pathways and played different roles in them. We selected most pathways CACNG4 participated on our site, such as MAPK signaling pathway,Cardiac muscle contraction,Adrenergic signaling in cardiomyocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with CACNG4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hypertrophic cardiomyopathy (HCM) | ITGA6,ITGA5,RYR2,ITGB3,LMNA,PRKAB1,ITGA10,CACNG7,ITGB4,ACTG1 |
| Cardiac muscle contraction | COX6A1,FXYD2,ATP1A4,CACNA1C,COX8C,COX6A2,MYH7,SLC8A1,CACNG8,COX4I1 |
| MAPK signaling pathway | TGFB2,CACNB2A,GNG12,PPM1AB,MAP4K2,FGF11,MAP3K13,PPP3CA,FGF20,RAC1B |
| Adrenergic signaling in cardiomyocytes | ATP1B2,CAMK2B1,MAPK14A,PPP1CB,TPM2,ATP1B3B,KCNQ1,MYL4,AGTR1A,CALM2A |
| Dilated cardiomyopathy | ITGA9,ITGA6,SLC8A1,CACNA2D2,ITGB7,ITGB1,ITGA8,TNF,ITGB8,MYH7 |
| Oxytocin signaling pathway | PRKAB1,RYR2,PLCB2,PIK3R3,CAMK2B,PPP3CC,GNAO1,RCAN1,CALML3,NPR1 |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | AASS,ITGA4,CDH2,CACNB3,ATP2A2,CACNG3,DSG2,ITGB3,ACTN4,ACTG1 |
Protein Function
CACNG4 has several biochemical functions, for example, channel regulator activity,voltage-gated calcium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CACNG4 itself. We selected most functions CACNG4 had, and list some proteins which have the same functions with CACNG4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| channel regulator activity | CACNG8,CACNG3,CNIH3,CACNG7A,CACNG8A,CACNG7,CACNG2A,SNF8,CACNG2B,CACNG2 |
| voltage-gated calcium channel activity | TMC1,CACNB2A,CACNB2B,CACNB4B,RYR1,CACNA1SA,CACNG1A,GAS6,CACNG2B,IL1RAPL1 |
Interacting Protein
CACNG4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CACNG4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CACNG4.
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References
- Aoki, Y; Yamada, E; et al. Multiple actions of extracellular ATP and adenosine on calcium currents mediated by various purinoceptors in neurons of nucleus tractus solitarius. NEUROSCIENCE RESEARCH 50:245-255(2004).
- Endoh, T; et al. Characterization of modulatory effects of postsynaptic metabotropic glutamate receptors on calcium currents in rat nucleus tractus solitarius. BRAIN RESEARCH 1024:212-224(2004).
