CACNA1H

  • Official Full Name

    calcium channel, voltage-dependent, T type, alpha 1H subunit

  • Overview

    Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells and their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage-gated ion channels, ligand-gated, other gating systems, and finally those that are classified differently, having more exotic characteristics. Cav3.2 is a protein which in humans is encoded by the CACNA1H gene. Studies suggest certain mutations in this gene lead to childhood absence epilepsy. Studies also suggest that the up-regulations of Cav3.2 may participate in the progession of prostate cancer toward an androgen-independent stage.

  • Synonyms

    CACNA1H;calcium channel, voltage-dependent, T type, alpha 1H subunit;voltage-dependent T-type calcium channel subunit alpha-1H;Cav3.2;voltage-gated calcium channel alpha subunit Cav3.2;voltage-gated calcium channel alpha subunit CavT.2;voltage-gated

Recombinant Proteins

  • Rat
  • Mouse
  • Human
  • Mammalian Cell
  • E.coli
  • HEK293
  • E. coli
  • His
  • His&GST
  • His&Flag
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
CACNA1H-1064R Recombinant Rat CACNA1H Protein Mammalian Cell Rat His
Cacna1h-1424M Recombinant Mouse Cacna1h protein, His & GST-tagged E.coli Mouse His&GST Ser2160~Val2359
CACNA1H-26604TH Recombinant Human CACNA1H, His-tagged E.coli Human His 2027-2347 a.a.
CACNA1H-1186HFL Recombinant Human CACNA1H protein, His&Flag-tagged HEK293 Human His&Flag 1-2347 aa
CACNA1H-2873H Recombinant Human CACNA1H protein, His-tagged E.coli Human His 1181-1280 aa
CACNA1H-2874H Recombinant Human CACNA1H protein, His-tagged E. coli Human His Arg1871-Asp2350
CACNA1H-728R Recombinant Rat CACNA1H Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
CACNA1H-728R-B Recombinant Rat CACNA1H Protein Pre-coupled Magnetic Beads HEK293 Rat

    Involved Pathway

    CACNA1H involved in several pathways and played different roles in them. We selected most pathways CACNA1H participated on our site, such as MAPK signaling pathway,Calcium signaling pathway,Circadian entrainment, which may be useful for your reference. Also, other proteins which involved in the same pathway with CACNA1H were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Aldosterone synthesis and secretion ITPR3,ATF6B,ADCY9,ITPR2,DDX1,CREB3L3,ADCY6,CYP21A2,CREB3L4,CYP11A1
    MAPK signaling pathway FGFR2,FGF13A,MAPKAPK2A,CACNB4A,RASA1,ARRB2B,RAF1B,TAOK1,GADD45B,CACNG7
    Calcium signaling pathway PTGFR,GRIN1,ATP2A2,ERBB4A,CACNA1D,PLCG2,TACR2,Adcy4,PLCD4,PTGER1B
    Circadian entrainment PLCB3,GNG13,GUCY1A3,ITPR1,Adcy4,MAPK3,GRIA2,GRIA4,CALML5,PLCB4

    Protein Function

    CACNA1H has several biochemical functions, for example, low voltage-gated calcium channel activity,metal ion binding,scaffold protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CACNA1H itself. We selected most functions CACNA1H had, and list some proteins which have the same functions with CACNA1H. You can find most of the proteins on our site.

    Function Related Protein
    scaffold protein binding ATP2B4,NLGN3,TREM1,IKBKB,CAV2,SCN5A,SHANK3,NLGN1,GRID2,NLRP1
    metal ion binding PVALB1,TKTL1,LENG9,ZNF397,ITPK1A,HENMT1,SDHDA,LIAS,ZFP239,ZNF652
    low voltage-gated calcium channel activity CACNA1G

    Interacting Protein

    CACNA1H has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CACNA1H here. Most of them are supplied by our site. Hope this information will be useful for your research of CACNA1H.

    PPP3CB;MAPK15

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