CA5B
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Official Full Name
carbonic anhydrase VB, mitochondrial -
Overview
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide.They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid.They show extensive diversity in tissue distribution and in their subcellular localization.CA VB is localized in the mitochondria and shows the highest sequence similarity to the other mitochondrial CA, CA VA.It has a wider tissue distribution than CA VA, which is restricted to the liver.The differences in tissue distribution suggest that the two mitochondrial carbonic anhydrases evolved to assume different physiologic roles. -
Synonyms
CA5B;carbonic anhydrase VB, mitochondrial;carbonic anhydrase 5B, mitochondrial;Carbonate dehydratase VB;Carbonic anhydrase VB;CA VB;carbonic dehydratase;CA-VB
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- HEK293T
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
CA5B involved in several pathways and played different roles in them. We selected most pathways CA5B participated on our site, such as Metabolism,Nitrogen metabolism,Reversible hydration of carbon dioxide, which may be useful for your reference. Also, other proteins which involved in the same pathway with CA5B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Nitrogen metabolism | CA13,CAR3,CA6,GLUD2,Car8,CA5,CAHZ,Car12,CAR1,CA1 |
| Metabolism | UGT1B3,AGPAT6,ADSL,CYP2R1,SULT1B1,DHCR7,ITPKB,LMF1,SULT1ST5,KIAA1199 |
| Reversible hydration of carbon dioxide | CA13 |
Protein Function
CA5B has several biochemical functions, for example, carbonate dehydratase activity,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CA5B itself. We selected most functions CA5B had, and list some proteins which have the same functions with CA5B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| carbonate dehydratase activity | CAHZ,CA4,Car9,Car8,CAR15,CAR6,CA15A,CA5,Car4,Car12 |
| zinc ion binding | TAF2,RNF187,CPO,RARGA,NR2F1,NR1D2B,ZNF257,RAD18,BHMT,PML |
Interacting Protein
CA5B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CA5B here. Most of them are supplied by our site. Hope this information will be useful for your research of CA5B.
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References
- Durdagi, S; Scozzafava, G; et al. Inhibition of mammalian carbonic anhydrases I-XIV with grayanotoxin III: solution and in silico studies. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 29:469-475(2014).
- van Karnebeek, CD; Sly, WS; et al. Mitochondrial Carbonic Anhydrase VA Deficiency Resulting from CA5A Alterations Presents with Hyperammonemia in Early Childhood. AMERICAN JOURNAL OF HUMAN GENETICS 94:453-461(2014).
