C1R
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Official Full Name
complement component 1, r subcomponent -
Overview
C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system. -
Synonyms
C1R;complement component 1, r subcomponent;complement C1r subcomponent
Recombinant Proteins
- Human
- Zebrafish
- Mammalian Cells
- Human Serum
- Wheat Germ
- HEK293
- E.coli
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| C1R-718H |
Active Recombinant Human C1R, His-tagged
|
Mammalian Cells | Human | His | 1-705 a.a. |
|
| C1R-96H |
Active Native Human C1r Enzyme
|
Human Serum | Human | Non |
|
|
| C1R-26129TH | Recombinant Human C1R | Wheat Germ | Human | Non | 705 amino acids |
|
| C1R-3265Z | Recombinant Zebrafish C1R | Mammalian Cells | Zebrafish | His |
|
|
| C1R-8133HCL | Recombinant Human C1R 293 Cell Lysate | HEK293 | Human | Non |
|
|
| C1R-0280H | Recombinant Human C1R Protein (Ala356-Asp705), N-His-tagged | E.coli | Human | His | Ala356-Asp705 |
|
| C1R-2571H | Recombinant Human C1R Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
|
|
| C1R-2571H-B | Recombinant Human C1R Protein Pre-coupled Magnetic Beads | HEK293 | Human |
|
||
| C1R-2666H | Active Recombinant Human C1R protein, His-tagged | HEK293 | Human | His | Met1-Asp705 |
|
| C1R-41HF | Recombinant Full Length Human C1R Protein | In Vitro Cell Free System | Human | Full L. 705 amino acids |
|
Involved Pathway
C1R involved in several pathways and played different roles in them. We selected most pathways C1R participated on our site, such as Phagosome,Complement and coagulation cascades,Pertussis, which may be useful for your reference. Also, other proteins which involved in the same pathway with C1R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Complement and coagulation cascades | C8G,C1S,CD59A,SERPIND1,VWF,MASP1,C5,CR1,F7,PLG |
| Staphylococcus aureus infection | ICAM1,GM5077,HLA-DRA,FCAR,FCGR1A,SELP,H2-AB1,DSG1A,FCGR2A,HLA-DRB4 |
| Phagosome | ATP6AP1,HLA-DRB1,ATP6V0C,TUBA8L2,Cd209g,CTSL1B,BLA,CD209A,ATP6V1C2,ITGB2L |
| Systemic lupus erythematosus | HIST3H2BB-PS,HIST1H3C,H3F3A,GM14477,C1S,H2AFY,GRIN2B,HIST1H4B,HIST1H4M,HLA-DQA1 |
| Pertussis | SERPING1,Casp3,FOS,IRF8,C1QA,AMCF-II,MAPK10,TICAM2,IL6,IRAK4 |
Protein Function
C1R has several biochemical functions, for example, calcium ion binding,protein binding,serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by C1R itself. We selected most functions C1R had, and list some proteins which have the same functions with C1R. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | EDIL3,SYT10,PCDHB13,GSNA,PCDH2G10,PCDH2AB12,PCDH2G9,EFCAB2,Shh,CDH7 |
| serine-type peptidase activity | PRSS12,GZMC,ELA2L,MCPT9,TPSG1,TMPRSS11G,CMA1,KLK4,Acr,GZMM |
| protein binding | C19orf73,GRIP1,FBF1,SLC4A1AP,PFKM,EMX2,FAM111A,DSN1,KIAA1274,AP5Z1 |
| serine-type endopeptidase activity | PCSK5B,CTSC,Acr,GZMC,HPN,TMPRSS2,PRSS57,GZMF,KLK1B1,HTRA1 |
Interacting Protein
C1R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with C1R here. Most of them are supplied by our site. Hope this information will be useful for your research of C1R.
C1S;N/A;calcium(2+);PCK1;EP300;d-mannose
Resources
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References
- Keizer, MP; Pouw, RB; et al. TFPI inhibits lectin pathway of complement activation by direct interaction with MASP-2. EUROPEAN JOURNAL OF IMMUNOLOGY 45:544-550(2015).
- Muia, J; Zhu, J; et al. Allosteric activation of ADAMTS13 by von Willebrand factor. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:18584-18589(2014).
