BRPF3
-
Official Full Name
bromodomain and PHD finger containing, 3 -
Synonyms
BRPF3;bromodomain and PHD finger containing, 3;bromodomain and PHD finger-containing protein 3;KIAA1286;Bromodomain and PHD finger containing protein 3
Recombinant Proteins
- Human
- E. coli
- E.coli
- N-His&C-FLAG
- GST
- His
- Non
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| BRPF3-1715H |
Recombinant Human BRPF3 protein, His&FLAG-tagged
|
E. coli | Human | N-His&C-FLAG | 576-701 aa |
|
| BRPF3-160H | Recombinant Human BRPF3, GST-tagged | E.coli | Human | GST | 576-701 a.a. |
|
| BRPF3-26105TH | Recombinant Human BRPF3, His-tagged | E.coli | Human | His | 869-1205 a.a. |
|
| BRPF3-60H | Recombinant Human BRPF3 protein, GST-tagged | E.coli | Human | GST | 588-703 |
|
| BRPF3-61H | Recombinant Human BRPF3 protein, His-tagged | E.coli | Human | His | 588-703 |
|
| BRPF3-182HCL | Recombinant Human BRPF3 cell lysate | Human | Non |
|
||
| BRPF3-1060H | Recombinant Human BRPF3 Protein (D1056-G1195), Tag Free | E.coli | Human | Non | D1056-G1195 |
|
| BRPF3-1061H | Recombinant Human BRPF3 Protein (D1056-G1195), His tagged | E.coli | Human | His | D1056-G1195 |
|
| Kit-1703 | BRPF3 Inhibitor Screening Assay Kit | Non |
|
|||
| Kit-1704 | BRPF3 TR-FRET Assay Kit | Non |
|
Involved Pathway
BRPF3 involved in several pathways and played different roles in them. We selected most pathways BRPF3 participated on our site, such as Chromatin modifying enzymes,Chromatin organization,HATs acetylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with BRPF3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Platelet activation, signaling and aggregation | TRPC6A,FCER1GL,F13A1B,C6orf25,WDR1,PLEK,SERPINF2B,PRKCHB,CD9A,AASS |
| Chromatin organization | KDM2A,KAT8,KAT6B,SMYD3,PAX3A,ATXN7L3,DPY30,EPC1,KANSL3,PRMT6 |
| Chromatin modifying enzymes | KAT5,ING3,RBB4L,BRD1,ATF7IP,DMAP1,TADA2B,TADA1,PADI1,KAT8 |
| Platelet degranulation | CD9A,TFA,SPARC,CLU,F13A1B,GAS6,HRG,F13A1A.1,SCG3,MMRN1 |
| Response to elevated platelet cytosolic Ca2+ | TFA,CD9B,SERPINF2B,SCG3,SPARC,CAP1,MMRN1,CALU,STXBP3A,WDR1 |
| Hemostasis | KIF2A,HBB-BH1,DGKB,DGKG,ABHD6B,PLEK,SERPINB8,SERPINF2B,IRF2,F13A1B |
| HATs acetylate histones | ING5,USP22,VPS72,ENY2,PHF20B,MSL2A,MORF4L1,TADA1,BRPF1,ANO9A |
Protein Function
BRPF3 has several biochemical functions, for example, protein binding,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BRPF3 itself. We selected most functions BRPF3 had, and list some proteins which have the same functions with BRPF3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CNIH4,PTGES3,PKHD1L1,NTN4,MAP4K5,METTL13,UBE2IB,VPS41,SAMM50,SCLY |
| zinc ion binding | THRA,ESRRA,CPB2,DTX3L,CA5B,RNF169,PDLIM7,ZMYM2,NR2F6,PRKCBA |
Interacting Protein
BRPF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BRPF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of BRPF3.
ABL1;FYN;NCK1;PIK3R1;GRB2;pdpC2;q7chb4_yerpe;opuD;WEE1;Mad2l1
Resources
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References
- Demont, EH; Bamborough, P; et al. 1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain. ACS MEDICINAL CHEMISTRY LETTERS 5:1190-1195(2014).
- Lubula, MY; Poplawaski, A; et al. Crystallization and preliminary X-ray diffraction analysis of the BRPF1 bromodomain in complex with its H2AK5ac and H4K12ac histone-peptide ligands. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS 70:1389-1393(2014).
