BLNK
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Official Full Name
B cell linker -
Overview
The B cell linker protein BLNK (also referred to as B cell adaptor containing Src homology 2 domain - BASH - or, SLP-65), is crucial for B cell antigen receptor (BCR)-mediated activation, proliferation, and differentiation of B cells. BLNK represents a ce -
Synonyms
BLNK;B cell linker;B-cell linker protein;lymphocyte antigen 57;cytoplasmic adapter protein;B-cell adapter containing a SH2 domain protein;B-cell adapter containing a Src homology 2 domain protein;src homology 2 domain-containing leukocyte protein of 65 kDa;Bca;BASH;Ly57;Ly-57;Lyw-57;SLP-65
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- Rat
- E.coli
- HEK293
- E. coli
- Mammalian Cell
- Wheat Germ
- Human Cell
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
BLNK involved in several pathways and played different roles in them. We selected most pathways BLNK participated on our site, such as NF-kappa B signaling pathway,Osteoclast differentiation,B cell receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BLNK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Osteoclast differentiation | TAB2,AKT1,TGFBR1,PLCG2,IL1B,IFNGR1,STAT1,NCF4,MAPK10,MAPK11 |
| B Cell Receptor Signaling Pathway | RASGRP3,MAP4K1,AKT2,MAP2K2,GSK3B,PIK3R3,PPP3CA,CR2,PTPN6, Cd79b |
| NF-kappa B signaling pathway | TRIM25,ERC1,TRAF5,CXCL2,IRAK4,LTBR,UBE2I,GM1987,TNFRSF1A,LRDD |
| nodeficiency | DCLRE1C,UNG, Cd79b,CD79A,CD19,TAP2,IL7R,ZAP70,IL2RG,ICOS |
| Primary i | CD8B,CD8A,PTPRC,RFXAP,AIRE,ZAP70,IL7R,TAP1,UNG,RAG2 |
Protein Function
BLNK has several biochemical functions, for example, SH3/SH2 adaptor activity,protein binding,transmembrane receptor protein tyrosine kinase adaptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BLNK itself. We selected most functions BLNK had, and list some proteins which have the same functions with BLNK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| SH3/SH2 adaptor activity | SKAP2,LAT,RUSC1,SOCS2,IRS4,ARHGAP4,SH2B2,SRC,SH2D2A,CRK |
| transmembrane receptor protein tyrosine kinase adaptor activity | TRAT1,DOK2,GAB2,SH2B2,STAP1,FRS2,PIK3R1,SHC1,IRS1 |
| protein binding | MET,DOK6,SOX4,GTF2E2,ALDH3B1,C10orf62,QARS,ALX1,TFAM,SERPINB5 |
Interacting Protein
BLNK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BLNK here. Most of them are supplied by our site. Hope this information will be useful for your research of BLNK.
GRB2;BTK;Grap2;SH3KBP1;CD2AP;q5zjw0_chick;ERBB2;AR
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References
- Wang, J; Sohn, H; et al. The autoinhibitory C-terminal SH2 domain of phospholipase C-gamma 2 stabilizes B cell receptor signalosome assembly. SCIENCE SIGNALING 7:-(2014).
- Luger, D; Yang, YA; et al. Expression of the B-Cell Receptor Component CD79a on Immature Myeloid Cells Contributes to Their Tumor Promoting Effects. PLOS ONE 8:-(2013).
