BEST3

  • Official Full Name

    bestrophin 3

  • Overview

    BEST3 belongs to the bestrophin family of anion channels, which includes BEST1 (MIM 607854), the gene mutant in;vitelliform macular dystrophy (VMD; MIM 153700), and 2 other BEST1-like genes, BEST2 (MIM 607335) and BEST4 (MIM;607336). Bestrophins are transmembrane (TM) proteins that share a homology region containing a high content of;aromatic residues, including an invariant arg-phe-pro (RFP) motif. The bestrophin genes share a conserved gene;structure, with almost identical sizes of the 8 RFP-TM domain-encoding exons and highly conserved exon-intron;boundaries. Each of the 4 bestrophin genes has a unique 3-prime end of variable length (Stohr et al., 2002 (PubMed;12032738); Tsunenari et al., 2003 (PubMed 12907679)).

  • Synonyms

    BEST3;bestrophin 3;vitelliform macular dystrophy 2 like 3 , VMD2L3;bestrophin-3;MGC13168;MGC40411;Vitelliform macular dystrophy 2 like protein 3;BEST 3;BEST3_HUMAN;Bestrophin3;OTTHUMP00000195114;OTTHUMP00000233491;Vitelliform macular dystrophy 2 like 3;Vitelliform macular dystrophy 2-like protein 3;VMD2L3;vitelliform macular dystrophy 2-like 3

Recombinant Proteins

  • Human
  • Mouse
  • Chicken
  • Mus musculus
  • E.coli
  • Mammalian Cell
  • HEK293
  • HEK293T
  • E.coli expression system
  • His
  • Non
  • His&Fc&Avi
  • Myc&DDK
  • His&GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
BEST3-10209H Recombinant Human BEST3, His-tagged E.coli Human His C-term-186a.a.
BEST3-2378M Recombinant Mouse BEST3 Protein Mammalian Cell Mouse His
BEST3-4453C Recombinant Chicken BEST3 Mammalian Cell Chicken His
BEST3-8466HCL Recombinant Human BEST3 293 Cell Lysate HEK293 Human Non
BEST3-1014M Recombinant Mouse BEST3 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
BEST3-1014M-B Recombinant Mouse BEST3 Protein Pre-coupled Magnetic Beads HEK293 Mouse
Best3-1860M Recombinant Mouse Best3 Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
BEST3-3094H Recombinant Human BEST3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
Best3-313M Recombinant Mouse Best3 Protein, His&GST-tagged E.coli Mouse His&GST Glu507-Phe669
RFL10127MF Recombinant Full Length Mouse Bestrophin-3(Best3) Protein, His-Tagged E.coli expression system Mus musculus His Full L. Full Length (1-669)
RFL34325HF Recombinant Full Length Human Bestrophin-3(Best3) Protein, His-Tagged E.coli expression system Human His Full L. Full Length (1-668)

    Involved Pathway

    BEST3 involved in several pathways and played different roles in them. We selected most pathways BEST3 participated on our site, such as Ion channel transport,Stimuli-sensing channels,Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with BEST3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Transmembrane transport of small molecules FXYD7,SLC22A18,SLC35A3A,ANO7,SLC1A7A,OSTM1,SLC43A2,NHEDC1,SLC9A3.2,SLC39A2
    Stimuli-sensing channels TRPA1A,TRPC4,ANO8,CLCN2,MCOLN2,TRPC4A,TRPC5A,OSTM1,ASPH,NHEDC1
    Ion channel transport SLC17A3,UNC79,ASPH,FXYD3,BSND,TRPM1B,ATP1A1A.4,SRI,SCNN1D,CCC2

    Protein Function

    BEST3 has several biochemical functions, for example, contributes_to chloride channel activity,molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by BEST3 itself. We selected most functions BEST3 had, and list some proteins which have the same functions with BEST3. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to chloride channel activity BEST4,GABRR2,GABRB3,GABRR3A,BEST1,GABRR2A,GABRB1,GABRQ,BSND,BEST2
    molecular_function CPNE9,HAUS2,DESI1A,SOWAHC,RSPH3B,FAM199X,TMEM232,IGFN1.1,TMEM106B,PAGE4

    Interacting Protein

    BEST3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BEST3 here. Most of them are supplied by our site. Hope this information will be useful for your research of BEST3.

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