BDKRB2
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Official Full Name
bradykinin receptor B2 -
Overview
This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein. [provided by RefSeq, Jul 2008] -
Synonyms
BDKRB2;bradykinin receptor B2;B2R;BK2;BK-2;BKR2;BRB2;B2 bradykinin receptor;BK-2 receptor
Recombinant Proteins
- Human
- Chicken
- Cynomolgus
- Guinea pig
- Sus scrofa (Pig)
- Mus musculus
- Rat
- Oryctolagus cuniculus (Rabbit)
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- E.coli
- E.coli expression system
- His
- GST
- Non
- His&Fc&Avi
- His&GST
Involved Pathway
BDKRB2 involved in several pathways and played different roles in them. We selected most pathways BDKRB2 participated on our site, such as Calcium signaling pathway,cGMP-PKG signaling pathway,Sphingolipid signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BDKRB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Complement and coagulation cascades | SERPINC1,C2,PLAUR,F2R,MBL2,SERPINA1A,F3,CR2,SERPING1,C1QB |
| Sphingolipid signaling pathway | GAB2,TNFRSF1A,AKT1,RAC2,MS4A2,SGPP2,PPP2R5D,FCER1G,ROCK1,LASS4 |
| Inflammatory mediator regulation of TRP channels | TRPM8,MAPK8,PLCB3,HTR2B,Adcy4,PRKCH,CYP4A14,PIK3R3,PRKCG,PLCG2 |
| Pathways in cancer | BIRC2,EGLN1,PIK3CG,FZD7,GNG4,CDC42,FZD2,LAMB2,WNT5B,VEGFB |
| Chagas disease (American trypanosomiasis) | TNFRSF1A,AKT2,PIK3CD,GNAI1,GNA15,C1QB,IL10,TLR9,Fasl,CCL3L1 |
| cGMP-PKG signaling pathway | ITPR3,ROCK2,GNAI3,NPPB,PPP3CC,PPP1CC,ATP1B4,PPP3R2,SLC25A6,ATP2A1 |
| Calcium signaling pathway | PPP3R1,MYLK2,DRD5,CACNA1D,EDNRB,PRKACG,PPP3CCB,CALML3,PLCB1,CALM2 |
| Endocrine and other factor-regulated calcium reabsorption | KLK1B1,PRKACA,PRKACB,KLK1B5,CALB1,ESR1,PLCB3,PLCB2,ATP1B3,KLK2 |
| Neuroactive ligand-receptor interaction | TAAR4,GRIN2B,MLNR,TAAR13E,NPY4R,TBXA2R,TACR1A,AVPR2,PTH1RB,C3AR1 |
Protein Function
BDKRB2 has several biochemical functions, for example, beta-2 adrenergic receptor binding,bradykinin receptor activity,phosphatidylinositol phospholipase C activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BDKRB2 itself. We selected most functions BDKRB2 had, and list some proteins which have the same functions with BDKRB2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphatidylinositol phospholipase C activity | PLCG1,PLCB3,PLCB1,PLCD1A,CCKBR,CCR1,PLD4,EDNRA,PLCD4,CHRM1 |
| type 1 angiotensin receptor binding | TYK2,ARAP1,AGT,ARRB2,GNA13,GNA13B,GNA13A,GNG3,JAK2,GNB1 |
| protein binding | BLMH,TRIM72,CDKN1A,NONO,LRRC4C,LRGUK,ZNF227,KCNJ9,IL-8,TFAM |
| protease binding | FAP,C10orf2,FN1,FADD,TYSND1,TNFAIP3,PEO1,TTN,INSL3,SERPINB3 |
| beta-2 adrenergic receptor binding | NEDD4,GNAS,PDE4D,SLC9A3R1 |
| bradykinin receptor activity | BDKRB1 |
| protein heterodimerization activity | GABPA,KCNH1,LIFR,BMP2,UBA3,UGT1A7,BOKB,SYCP2,NFE2L2A,INHA |
Interacting Protein
BDKRB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BDKRB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of BDKRB2.
npc-567;KNG1
Resources
Research Area
Peptide Receptors on Endothelial CellsPlasmin/Plasminogen and Kallikrein/Kinin Systems
Related Services
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References
- Veljkovic, V; Glisic, S; et al. Influenza vaccine as prevention for cardiovascular diseases: Possible molecular mechanism. VACCINE 32:6569-6575(2014).
- Marketou, ME; Kontaraki, J; et al. Differential gene expression of bradykinin receptors 1 and 2 in peripheral monocytes from patients with essential hypertension. JOURNAL OF HUMAN HYPERTENSION 28:450-455(2014).
