BCLAF1
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Official Full Name
BCL2-associated transcription factor 1 -
Overview
This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
BCLAF1;BCL2-associated transcription factor 1;bcl-2-associated transcription factor 1;BTF;KIAA0164;bK211L9.1
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| BCLAF1-3495H | Recombinant Human BCLAF1 protein, His-tagged | E.coli | Human | His | 881-920 aa | |
| BCLAF1-2358M | Recombinant Mouse BCLAF1 Protein | Mammalian Cell | Mouse | His |
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| BCLAF1-8475HCL | Recombinant Human BCLAF1 293 Cell Lysate | HEK293 | Human | Non |
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| BCLAF1-1003M | Recombinant Mouse BCLAF1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| BCLAF1-1003M-B | Recombinant Mouse BCLAF1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| BCLAF1-301423H | Recombinant Human BCLAF1 protein, GST-tagged | E.coli | Human | GST | Ser881-Glu920 |
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Involved Pathway
BCLAF1 involved in several pathways and played different roles in them. We selected most pathways BCLAF1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with BCLAF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
BCLAF1 has several biochemical functions, for example, DNA binding,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BCLAF1 itself. We selected most functions BCLAF1 had, and list some proteins which have the same functions with BCLAF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | ARID4A,HIST1H2BA,PMS2,SUPT3H,ZFP335,CLOCKA,ZNF354A,POU3F3A,ZBTB42,YY1 |
| poly(A) RNA binding | RPL19,RALY,OASL,UPF1,SRSF4,LLPH,COX4I2,MKRN1,ISY1,SRSF9 |
| protein binding | CEP63,PPP6R3,ACSS1,EFNA4,AP1S2,PSMA4,CDK9,IRAK1BP1,PLAA,CYB5R2 |
Interacting Protein
BCLAF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCLAF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BCLAF1.
SNW1;THRAP3;EMD;YWHAG;SNIP1;BCL2
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References
- Tanaka, T; Shibazaki, A; et al. HSP70 mediates degradation of the p65 subunit of nuclear factor kappa B to inhibit inflammatory signaling. SCIENCE SIGNALING 7:-(2014).
- Tsui, KH; Lin, LT; et al. Gene expression of cumulus cells in women with poor ovarian response after dehydroepiandrosterone supplementation. Taiwanese Journal of Obstetrics & Gynecology 53:559-565(2014).
