BCL2A1
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Official Full Name
BCL2-related protein A1 -
Overview
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
BCL2A1;BCL2-related protein A1;GRS;BFL1;ACC-1;ACC-2;HBPA1;BCL2L5;bcl-2-related protein A1;bcl2-L-5;protein BFL-1;bcl-2-like protein 5;hematopoietic BCL2-related protein A1;hemopoietic-specific early response protein
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
- His&GST
Involved Pathway
BCL2A1 involved in several pathways and played different roles in them. We selected most pathways BCL2A1 participated on our site, such as NF-kappa B signaling pathway,Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with BCL2A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcriptional misregulation in cancer | NUPR1,SIX4,TRAF1,RUNX2,IL-8,CDK14,IL2RB,WT1,PAX3,HMGA2 |
| NF-kappa B signaling pathway | CD40,LAT,IRAK4,LTBR,Ccl21c,TRADD,VCAM1,CXCL2,ZAP70,CCL4 |
Protein Function
BCL2A1 has several biochemical functions, for example, protein binding,protein heterodimerization activity,protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BCL2A1 itself. We selected most functions BCL2A1 had, and list some proteins which have the same functions with BCL2A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ADAT2,PRKCD,PKP2,HINFP,RASGRP3,BAG5,DHDDS,PDCD10,MLF1IP,FLRT3 |
| protein homodimerization activity | CECR1,PRPS2,ABAT,CADM2A,ACTN3,LRP4,TIMM9,RPS19,GZMA,FZD1 |
| protein heterodimerization activity | HIST1H3A,UBA2,BAK1,ENO2,H2BFWT,P2RY1,CAV2,HIST1H4C,ADRA1B,TAS1R2 |
Interacting Protein
BCL2A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCL2A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BCL2A1.
BIK;BAK1;FAM9B;BCL2L11;BID;BBC3;NR4A1;q9wmx2-pro_0000037548
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References
- Mannam, VKR; Lewis, RE; et al. The fate of renal allografts hinges on responses of the microvascular endothelium. EXPERIMENTAL AND MOLECULAR PATHOLOGY 94:398-411(2013).
- Medina-Echeverz, J; Haile, LA; et al. IFN-gamma regulates survival and function of tumor-induced CD11b(+)Gr-1(high) myeloid derived suppressor cells by modulating the anti-apoptotic molecule Bcl2a1. EUROPEAN JOURNAL OF IMMUNOLOGY 44:2457-2467(2014).
