BCL11A

  • Official Full Name

    B-cell CLL/lymphoma 11A (zinc finger protein)

  • Overview

    This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene.

  • Synonyms

    BCL11A;B-cell CLL/lymphoma 11A (zinc finger protein);ecotropic viral integration site 9 , EVI9;B-cell lymphoma/leukemia 11A;BCL11A L;BCL11A S;BCL11A XL;CTIP1;HBFQTL5;ZNF856;EVI-9;BCL-11A;zinc finger protein 856;C2H2-type zinc finger protein

Recombinant Proteins

  • Human
  • Chicken
  • Mouse
  • E.coli
  • Wheat Germ
  • Mammalian Cell
  • In Vitro Cell Free System
  • HEK293
  • HEK293T
  • His
  • GST
  • Non
  • Myc&DDK
Cat.# Product name Source (Host) Species Tag Protein Length Price
BCL11A-1241H Recombinant Human BCL11A protein, His-tagged E.coli Human His Met1~Arg210
BCL11A-142H Recombinant Human BCL11A Protein, GST-tagged Wheat Germ Human GST
BCL11A-2711C Recombinant Chicken BCL11A Mammalian Cell Chicken His
BCL11A-28026TH Recombinant Human BCL11A Wheat Germ Human Non 88 amino acids
BCL11A-164HCL Recombinant Human BCL11A cell lysate Human Non
BCL11A-1587HF Recombinant Full Length Human BCL11A Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 243 amino acids
BCL11A-2470H Recombinant Human BCL11A Protein, MYC/DDK-tagged HEK293 Human Myc&DDK
BCL11A-5349H Recombinant Human BCL11A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
Bcl11a-984M Recombinant Mouse Bcl11a Protein, MYC/DDK-tagged HEK293T Mouse Myc&DDK

    Involved Pathway

    BCL11A involved in several pathways and played different roles in them. We selected most pathways BCL11A participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with BCL11A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    Protein Function

    BCL11A has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BCL11A itself. We selected most functions BCL11A had, and list some proteins which have the same functions with BCL11A. You can find most of the proteins on our site.

    Function Related Protein
    metal ion binding KLF17,RIOK3,ATP2B1,MYCBP2,CYP2C37,CYP2J6,ZNF157,CBFA2T2,GNAS,FHL2B
    protein binding ELK4,PACSIN2,ESYT1,STRA13,RAP2B,ZNF394,RGS6,SLX4,FNIP1,BRCA2
    RNA polymerase II core promoter proximal region sequence-specific DNA binding ELF3,RELA,TFE3B,KLF16,ATF7,RFX1A,CARF,JUNBB,RAX,HAND1
    protein heterodimerization activity HOMER1,PRMT8,NFYBB,IKZF3,SLC3A1,RRAGC,HIST1H2AL,ADRa1A,P2RY1,PRPH
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding NFE2L3,BHLHE40,MXD1,HELT,CC2D1B,CTCF,EN1,NKX6,NKX3-2,POU4F2
    transcription corepressor activity LMCD1,NPAT,SF1,SSX5,POU1F1,LHX1,CSDA,TBL1XR1A,BATF3,SFMBT1
    protein homodimerization activity ABP1,GRPEL1,UBE4A,SDCBP,BAXB,ERCC5,ZFP365,CD8A,PON1,BNIP3L

    Interacting Protein

    BCL11A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCL11A here. Most of them are supplied by our site. Hope this information will be useful for your research of BCL11A.

    CDK4;CDK6;hbg2_human_dna;ACTC1;q8czv1_yerpe;YME1L1;CDCA3;AIM2;BCL6;HDAC1;HDAC2

    Resources

    Gene Families

    What Is BCL2 Gene Family

    References

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