BCAR1
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Official Full Name
breast cancer anti-estrogen resistance 1 -
Overview
BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including migration, survival, transformation, and invasion (Sawada et al., 2006 [PubMed 17129785]).[supplied by OMIM, May 2009] -
Synonyms
BCAR1;breast cancer anti-estrogen resistance 1;CAS;CAS1;CASS1;CRKAS;P130Cas;breast cancer anti-estrogen resistance protein 1;Crk-associated substrate p130Cas;Cas scaffolding protein family member 1
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- Mammalian cells
- In Vitro Cell Free System
- HEK293T
- His
- GST
- Non
- Flag
- Myc&DDK
- His&Fc&Avi
Involved Pathway
BCAR1 involved in several pathways and played different roles in them. We selected most pathways BCAR1 participated on our site, such as Rap signaling pathway,Chemokine signaling pathway,Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with BCAR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Rap signaling pathway | FGF16,PIK3R5,INS2,RAP1A,LPAR2,PDGFD,AKT2,RAP1B,Adcy4,CALM2 |
| Focal adhesion | PIK3R2,MYLK2,GRB2,RAP1AB,ACTN1,GSK3B,ACTN3,VWF,MYLK,ILK |
| Regulation of Actin Cytoskeleton | ITGB5,ITGA2B,ITGB7,ARHGAP35,FGF1,CYFIP1,RHOAA,ITGB6,FGF7,ITGAX |
| Leukocyte transendothelial migration | ACTN3,ITGB2,RAP1A,MYL10,PLCG2,ESAM,GNAI3,RAC2,MAPK11,ACTB |
| Chemokine signaling pathway | GRK4,NFKB1,ITK,FOXO3,LOC100033925,CXCL9,CX3CL1,PLCB2,GNGT1,STAT1 |
| Bacterial invasion of epithelial cells | SEPT9,ARPC1B,ELMO3,WASF1,CRKL,SHC3,PIK3CG,ARPC3,ITGA5,ACTB |
Protein Function
BCAR1 has several biochemical functions, for example, SH3 domain binding,protein binding,protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BCAR1 itself. We selected most functions BCAR1 had, and list some proteins which have the same functions with BCAR1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| SH3 domain binding | SIRPA,FUT8,SH3BGR,DRD4,SH2D2A,VASPA,SHANK3,PLSCR4,SH3BP5L,KHDRBS3 |
| protein kinase binding | MAPK4,CYLD,AKAP5,H2AFY,GATA6,CALM3,CDK5,TSACC,CADPS,PRKACA |
| protein binding | PEF1,CCDC11,FAM13C,B9D2,MPDZ,TMEM67,BRD8,CENPH,PYCARD,FCN1 |
| signal transducer activity | TAS2R114,GPR34L,OLFR495,MIER1A,GNG2,TACR3A,GNG12A,PLCD3,PLCL2,HTR5AL |
Interacting Protein
BCAR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCAR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BCAR1.
PTPN1;CRK;SRC;FYN;PTPN12
BCAR1 Related Signal Pathway
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References
- Jardel, P; Debiais, C; et al. Ductal carcinoma of the prostate shows a different immunophenotype from high grade acinar cancer. HISTOPATHOLOGY 63:57-63(2013).
- van Agthoven, T; Godinho, MFE; et al. Protein pathway activation mapping reveals molecular networks associated with antiestrogen resistance in breast cancer cell lines. INTERNATIONAL JOURNAL OF CANCER 131:1998-2007(2012).
