BAIAP2L1
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Official Full Name
BAI1-associated protein 2-like 1 -
Overview
This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation. -
Synonyms
BAIAP2L1;BAI1-associated protein 2-like 1;brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1;IRTKS;BAI1-associated protein 2-like protein 1;insulin receptor tyrosine kinase substrate;FLJ42275
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- HEK293T
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
BAIAP2L1 involved in several pathways and played different roles in them. We selected most pathways BAIAP2L1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with BAIAP2L1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
BAIAP2L1 has several biochemical functions, for example, actin binding,cytoskeletal adaptor activity,proline-rich region binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BAIAP2L1 itself. We selected most functions BAIAP2L1 had, and list some proteins which have the same functions with BAIAP2L1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytoskeletal adaptor activity | SORBS2,ABI2,NCK1,ANK1,BAIAP2L1B,BAIAP2L2,BAIAP2L1A,BAIAP2,BICD1,BIN3 |
| protein binding | RASSF3,ORAI2,KL,ATP11C,PIK3IP1,ELAVL1,NUP107,MYO1C,Siglec1,CLIC5 |
| proline-rich region binding | CSK,GHR,PRPF40A,GAREM,WBP4,ITSN1,ABL1,PFN1,ABI2,TCERG1 |
| actin binding | BCL7B,ABLIM1B,MYH15,EPS8L1,MYO5C,EPB41L1,SCINLA,PPP1R9B,MYH8,SVILA |
Interacting Protein
BAIAP2L1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BAIAP2L1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BAIAP2L1.
tir;FASLG;PRKAB2;PRKAA2;tir;q81mi3_bacan;Ubr5;Iqgap3;PSMD14;TACC1;Cdc6;ZWINT;Hsf1;BAG6;Tnpo1;ESR2;SGTB;IP6K3
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