BAG4

  • Official Full Name

    BCL2-associated athanogene 4

  • Overview

    The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified.

  • Synonyms

    BAG4;BCL2-associated athanogene 4;BAG family molecular chaperone regulator 4;silencer of death domains;SODD;bcl-2-associated athanogene 4;BAG-family molecular chaperone regulator-4;BAG-4;DKFZp586O2022

Recombinant Proteins

  • Human
  • Mouse
  • Zebrafish
  • E. coli
  • Wheat Germ
  • E.coli
  • Mammalian Cell
  • HEK293
  • In Vitro Cell Free System
  • HEK293T
  • His
  • GST
  • His&T7
  • Non
  • Myc&DDK
Cat.# Product name Source (Host) Species Tag Protein Length Price
BAG4-01H Recombinant Human BAG4 Protein, His-tagged E. coli Human His 122-457 aa
BAG4-055H Recombinant Human BAG4 protein, GST-tagged Wheat Germ Human GST
Bag4-1421M Recombinant Mouse Bag4 protein, His & T7-tagged E.coli Mouse His&T7 Ser210~Ala447
BAG4-8194Z Recombinant Zebrafish BAG4 Mammalian Cell Zebrafish His
BAG4-8526HCL Recombinant Human BAG4 293 Cell Lysate HEK293 Human Non
BAG4-1803HF Recombinant Full Length Human BAG4 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 457 amino acids
Bag4-1818M Recombinant Mouse Bag4 Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
BAG4-4771H Recombinant Human BAG4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK

    Involved Pathway

    BAG4 involved in several pathways and played different roles in them. We selected most pathways BAG4 participated on our site, such as TNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BAG4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    TNF signaling pathway IKBKG,PIK3CG,AKT2,NFKBIA,CX3CL1,PIK3R3,CFLAR,ATF4,BIRC3,TAB2

    Protein Function

    BAG4 has several biochemical functions, for example, chaperone binding,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BAG4 itself. We selected most functions BAG4 had, and list some proteins which have the same functions with BAG4. You can find most of the proteins on our site.

    Function Related Protein
    chaperone binding DNAJA2L,VWF,PFDN4,HLA-B,TBCC,AMFR,DNAJA3B,BAG2,TSACC,CDC37L1
    receptor signaling protein activity DOK5,Siglece,ADCYAP1,ADRB1,BAG1,GNAZ,CD3E,DOK1,RAF1A,CD19
    poly(A) RNA binding VSIG8,SR140,NOP14,CNBP,PPHLN1,RTF1,MRPL45,DDX39,DDX17,LLPH
    protein binding HADHB,BIRC3,THEM5,FAM118A,RABL2A,AZI2,SULT1B1,Trf,MYO15,C1QL1
    ubiquitin protein ligase binding LTBR,CUL3A,AXIN2,FHIT,CBS,STUB1,GPI,GRIK2,EGFR,PER3

    Interacting Protein

    BAG4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BAG4 here. Most of them are supplied by our site. Hope this information will be useful for your research of BAG4.

    DCP1A;HSPA2;DNAJC7;b3ktt5_human;TET3;HSF2;SIM2;STK11;q53fc7_human;q5c8s5_human;DCP1B;GLCE;LYPD3;DIRAS3

    Resources

    References

    • Etokebe, GE; Bulat-Kardum, L; et al. Association of Variable Number of Tandem Repeats in the Coding Region of the FAM46A Gene, FAM46A rs11040 SNP and BAG6 rs3117582 SNP with Susceptibility to Tuberculosis. PLOS ONE 9:-(2014).
    • Yang, JL; Zhang, W; et al. New molecular insights into osteosarcoma targeted therapy. CURRENT OPINION IN ONCOLOGY 25:398-406(2013).

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