BAG3
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Official Full Name
BCL2-associated athanogene 3 -
Overview
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008] -
Synonyms
BAG3;BCL2-associated athanogene 3;BIS;MFM6;BAG-3;CAIR-1;BAG family molecular chaperone regulator 3;docking protein CAIR-1;BCL2-binding athanogene 3;bcl-2-binding protein Bis
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Zebrafish
- E.coli
- Wheat Germ
- Mammalian Cell
- Yeast
- HEK293
- In Vitro Cell Free System
- HEK293T
- Mammalian cells
- His
- GST
- His&SUMO
- Non
- Myc&DDK
- His&Fc&Avi
- Flag
Involved Pathway
BAG3 involved in several pathways and played different roles in them. We selected most pathways BAG3 participated on our site, such as Apoptosis Modulation and Signaling,Cellular response to heat stress,Cellular responses to stress, which may be useful for your reference. Also, other proteins which involved in the same pathway with BAG3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of HSF1-mediated heat shock response | HSPA13,HSPA7,HSPH1,KIAA1967,RPS19BP1,HSPA14,DNAJC7,DNAJB6,HSPA12B,C11orf73 |
| Cellular responses to stress | PRDX3,CBX8,EED,HIF3A,IGFBP7,HTATIP,DNAJC2,TINF2,ATG7,HSPA13 |
| Cellular response to heat stress | NUPL2,DNAJC7,HDAC6,HSBP1A,PTGES3,KIAA1967,DNAJC2,HSPA13,ST13,HSPH1 |
| Apoptosis Modulation and Signaling | HRK,PTPN13,BOK,BLK,DFFA,CRADD,BCL2L10,CDKN2A,PTRH2,HN1 |
Protein Function
BAG3 has several biochemical functions, for example, chaperone binding,protein binding,protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BAG3 itself. We selected most functions BAG3 had, and list some proteins which have the same functions with BAG3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein complex binding | AP2B1,PCSK2,NFYB,OTOF,CFLAR,PEX26,CAPG,FGFR1,CEBPA,THRA |
| protein binding | OAZ1,TSPAN4,MAGI1,GADD45B,SUPT6H,MRPL13,RBM10,KCNJ4,FGF19,C3orf52 |
| chaperone binding | ST13,C1orf182,TSC1,HSPD1,TRP53,PIH1D3,TIMM10,PRNP,DNAJA2L,DNAJB2 |
Interacting Protein
BAG3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BAG3 here. Most of them are supplied by our site. Hope this information will be useful for your research of BAG3.
HSPB8;HSPB1;DAZAP2;STUB1;PDE9A
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