B4GALT7
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Official Full Name
xylosylprotein beta1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I) -
Overview
Beta-1,4-galactosyltransferase 1 is an enzyme that in humans is encoded by the B4GALT1 gene. This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene is unique among the beta4GalT genes because it encodes an enzyme that participates both in glycoconjugate and lactose biosynthesis. For the first activity, the enzyme adds galactose to N-acetylglucosamine residues that are either monosaccharides or the nonreducing ends of glycoprotein carbohydrate chains. The second activity is restricted to lactating mammary tissues where the enzyme forms a heterodimer with alpha-lactalbumin to catalyze UDP-galactose + D-glucose <=> UDP + lactose. The two enzymatic forms result from alternate transcription initiation sites and post-translational processing. Two transcripts, which differ only at the 5' end, with approximate lengths of 4.1 kb and 3.9 kb encode the same protein. The longer transcript encodes the type II membrane-bound, trans-Golgi resident protein involved in glycoconjugate biosynthesis. The shorter transcript encodes a protein which is cleaved to form the soluble lactose synthase. -
Synonyms
B4galt7;xylosylprotein beta1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I);EDSP1;XGPT1;XGALT1;B4GALT7;xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7
Recombinant Proteins
- Human
- Chicken
- Rhesus macaque
- Zebrafish
- Mouse
- Wheat Germ
- Mammalian Cell
- HEK293
- HEK293T
- In Vitro Cell Free System
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
B4GALT7 involved in several pathways and played different roles in them. We selected most pathways B4GALT7 participated on our site, such as A tetrasaccharide linker sequence is required for GAG synthesis,Chondroitin sulfate/dermatan sulfate metabolism,Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate, which may be useful for your reference. Also, other proteins which involved in the same pathway with B4GALT7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism | ECI1,SLC25A1A,SLC19A2,NUDT10,NAT2,AGPAT6,FABP11B,CYP2N13,CYP3C1,STAB2 |
| Chondroitin sulfate/dermatan sulfate metabolism | AGRN,B3GAT2,Gpc2,BGNA,BGN,GPC1B,CHST9,DSEL,CSPG4,DCN |
| Metabolic pathways | COX5A,GCSH,MINPP1B,GALNT5,HEXA,FH,GBA2,AGPAT5,CYP8B1,GPAM |
| Heparan sulfate/heparin (HS-GAG) metabolism | Gpc2,SLC35D2,HS3ST6,B3GAT2,MAPK1IP1L,GPC5A,GPC1B,HPSE,GLB1L,HS3ST4 |
| Glycosaminoglycan metabolism | DSEL,BGNA,B3GNT2A,BGNB,GPC5A,OGN,LYVE1,HS3ST6,GPC1B,B3GAT2 |
| Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate | CSGALNACT1,CHSY3,CHST12,CHST14,XYLT1,XYLT2,CHST11,CHST3,CHST15,CHSY1 |
| A tetrasaccharide linker sequence is required for GAG synthesis | Gpc2,CSPG5,BGNA,CSPG4,VCANB,GPC5A,NCAN,BGN,B3GAT2,DCN |
| Glycosaminoglycan biosynthesis - heparan sulfate / heparin | HS6ST1,B3GALT6,EXT1C,XYLT1,NDST4,EXT1A,EXT1,HS6ST2,EXT1B,HS2ST1 |
Protein Function
B4GALT7 has several biochemical functions, for example, beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity,galactosyltransferase activity,manganese ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by B4GALT7 itself. We selected most functions B4GALT7 had, and list some proteins which have the same functions with B4GALT7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| galactosyltransferase activity | GTDC2,B3GNT8,B3GNT6,B3GNT3,B3GALNT2,4931440L10Rik,B3GALT6,B4GALT3,B4GALT4,B3GNT4 |
| manganese ion binding | MTPAP,PPM1BA,ARG1,GALNT2,ENDOU,GYLTL1B,SOD2,LAP3,NPEPL1,LARGE |
| protein binding | PIF1,DBNDD2,CCNG1,ALKBH6,APBA2,FAM125A,GDF2,ESRP1,PACSIN1,KRTAP5-9 |
| beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity | B4GALT2,WDFY3,B4GALT1,B4GALT3 |
Interacting Protein
B4GALT7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with B4GALT7 here. Most of them are supplied by our site. Hope this information will be useful for your research of B4GALT7.
RABGGTB;KRTAP10-7;Cep152;MYC;GBA;PCNA;EZR;ID1;YWHAZ;CDC16;Iffo2;THOC1;PEO1
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References
- Cartault, F; Munier, P; et al. Expanding the clinical spectrum of B4GALT7 deficiency: homozygous p.R270C mutation with founder effect causes Larsen of Reunion Island syndrome. EUROPEAN JOURNAL OF HUMAN GENETICS 23:49-53(2015).
- von Oettingen, JE; Tan, WH; et al. Skeletal dysplasia, global developmental delay, and multiple congenital anomalies in a 5-year-old boy-Report of the second family with B3GAT3 mutation and expansion of the phenotype. AMERICAN JOURNAL OF MEDICAL GENETICS PART A 164:1580-1586(2014).
