B4GALT3
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Official Full Name
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 -
Overview
This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene encodes an enzyme that may be mainly involved in the synthesis of the first N-acetyllactosamine unit of poly-N-acetyllactosamine chains. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. -
Synonyms
B4GALT3;UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3;beta-1,4-galactosyltransferase 3;beta4Gal T3;b4Gal T3;Beta 1,4 galactosyltransferase 3;Beta 1,4 GalTase 3;UDP Gal:beta GlcNAc beta-1,4 galactosyltransferase 3;b4Gal-T3;OTTHUMP00000032247;OTTHUMP00000032248;beta-1,4-GalTase 3;UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 3;beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase 3;UDP-galactose:beta-N-acetylglucos;beta4Gal-T3
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- Wheat Germ
- HEK293
- Mammalian Cell
- Mammalian cells
- HEK293T
- E.coli
- In Vitro Cell Free System
- E.coli expression system
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
B4GALT3 involved in several pathways and played different roles in them. We selected most pathways B4GALT3 participated on our site, such as N-Glycan biosynthesis,Other types of O-glycan biosynthesis,Glycosaminoglycan biosynthesis - keratan sulfate, which may be useful for your reference. Also, other proteins which involved in the same pathway with B4GALT3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Other types of O-glycan biosynthesis | B3GALTLA,COLGALT2,FUT7,GLT25D2,B3GALTLB,B3GALTL,CHST10,B3GALT4,B3GAT2,LFNG |
| Glycosaminoglycan biosynthesis - keratan sulfate | ST3GAL1,B4GALT2,CHST6,CHST2A,ST3GAL3,B3GNT7,B4GALT1,FUT8,Chst5,CHST2 |
| Metabolic pathways | UQCRC2,DGUOK,Cel,NME2A,ATP6V0E,MAN1A,AGPAT3,HYI,CBR3,ADO |
| Glycosphingolipid biosynthesis - lacto and neolacto series | FUT7,FUT9,ST8SIA1,FUT5,B3GNT3,B4GALT2,ST3GAL4,B3GNT5,FUT4,B4GALT4 |
| N-Glycan biosynthesis | MAN1C1,ZNF408,MOGS,MGAT3,MGAT1A,GANAB,MAN1A,ALG9,ALG10B,STT3A |
Protein Function
B4GALT3 has several biochemical functions, for example, N-acetyllactosamine synthase activity,beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity,galactosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by B4GALT3 itself. We selected most functions B4GALT3 had, and list some proteins which have the same functions with B4GALT3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity | WDFY3,B4GALT2,B4GALT7,B4GALT1 |
| galactosyltransferase activity | GALNT18A,B3GNT9-PS,B4GALT5,B3GALT6,B4GALT4,B3GNT7L,GLT8D1,C1GALT1,B4GALT7,B4GALT2 |
| metal ion binding | BMPR1A,EGR3,NRAP,ZBTB2A,GALNT12,ZNF547,ACACB,OAS2,ZNF609A,DRL |
| N-acetyllactosamine synthase activity | B4GALT2,B4GALT1,B4GALT4 |
Interacting Protein
B4GALT3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with B4GALT3 here. Most of them are supplied by our site. Hope this information will be useful for your research of B4GALT3.
SAT1;SURF2;purR2;nifJ;ARL15
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