B3GNT3
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Official Full Name
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 -
Overview
This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein and contains a signal anchor that is not cleaved. It prefers the substrates of lacto-N-tetraose and lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains and the biosynthesis of the backbone structure of dimeric sialyl Lewis a. It plays dominant roles in L-selectin ligand biosynthesis, lymphocyte homing and lymphocyte trafficking. -
Synonyms
B3GNT3;UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3;TMEM3;B3GN T3;B3GNT 3;beta 1;3 N acetylglucosaminyltransferase bGnT 3;beta3Gn T3;HP10328;putative type II membrane protein;transmembrane protein 3;B3GAL T8;B3GALT8;Beta 1,3 galactosyltransferase 8;Beta 3 Gal T8;Beta3Gal T8;Beta3GalT8;BGnT 3;BGnT3;Core 1 extending beta 1,3 N acetylglucosaminyltransferase;Core1 beta3GlcNAcT;UDP Gal:beta GlcNAc beta 1,3 galactosyltransferase 8;UDP GlcNAc:betaGal beta 1,3 N acetylglucosaminyltransferase 3;beta-3-Gx-T8;beta-1,3-Gn-T3;beta-1,3-GalTase 8;core1-beta3GlcNAcT;beta-1,3-N-acetylglucosaminyltransferase bGnT-3;UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 8;core 1 extending beta-1,3-N-acetylglucosaminyltransferase;UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 8;B3GN-T3;B3GNT-3;B3GAL-T8;beta3Gn-T3
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| B3GNT3-10104H | Recombinant Human B3GNT3, His-tagged | E.coli | Human | His | 34-372a.a. | |
| B3GNT3-020H | Recombinant Human B3GNT3 protein, GST-tagged | Wheat Germ | Human | GST |
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| B3GNT3-021H | Recombinant Human B3GNT3 protein, GST-tagged | Wheat Germ | Human | GST |
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| B3GNT3-2241M | Recombinant Mouse B3GNT3 Protein | Mammalian Cell | Mouse | His |
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| B3GNT3-6108Z | Recombinant Zebrafish B3GNT3 | Mammalian Cell | Zebrafish | His |
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| B3GNT3-8543HCL | Recombinant Human B3GNT3 293 Cell Lysate | HEK293 | Human | Non |
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| B3GNT3-1633HF | Recombinant Full Length Human B3GNT3 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 372 amino acids |
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| B3GNT3-291H | Recombinant Human B3GNT3 Protein, His-tagged | E.coli | Human | His | Leu165-Arg277 |
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| B3GNT3-930M | Recombinant Mouse B3GNT3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| B3GNT3-930M-B | Recombinant Mouse B3GNT3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
B3GNT3 involved in several pathways and played different roles in them. We selected most pathways B3GNT3 participated on our site, such as Glycosaminoglycan metabolism,Glycosphingolipid biosynthesis - lacto and neolacto series,Keratan sulfate biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with B3GNT3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycosphingolipid biosynthesis - lacto and neolacto series | B3GNT2B,B3GNT2,ST3GAL6,ST3GAL3,ABO,ST3GAL4,ST3GAL3B,B3GNT5B,B4GALT2,FUT7 |
| Metabolism of carbohydrates | HS3ST4,HAS1,SLC26A2,Gpc2,SLC35B3,MAPK1IP1L,SLC25A11,SLC25A1A,SLC35B2,TREH |
| Metabolism | CYGB2,BRSK2,ARSH,SPRB,PDK3,MAPK1IP1L,APOC2,GNG13A,GLYAT,UGT1B4 |
| Glycosaminoglycan metabolism | CHST14,CSPG5B,SLC26A2,KERA,B4GALT7,HPSE,SLC26A1,VCANB,Gpc2,UST |
| Keratan sulfate biosynthesis | SLC35D2,OGN,ST3GAL3A,OMD,KERA,B3GNT2A,FMODA,B3GNT2,PRELP,B3GNT1 |
| Metabolic pathways | NDUFV2,GALK1,GAMT,ASMT,AOX2P,RFK,CYP2J5,NDUFB3,AMY1A,POC1B-GALNT4 |
| Metabolism of proteins | IGFBP6B,ODAM,GATA6,ARSD,CCT7,TFG,ST3GAL3A,NSMCE4A,MUC1,SEC63 |
| Keratan sulfate/keratin metabolism | FMODA,OMD,B3GNT2A,GLB1L,ST3GAL3A,SLC35D2,B3GNT2,B3GNT1 |
Protein Function
B3GNT3 has several biochemical functions, for example, N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity,beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity,galactosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by B3GNT3 itself. We selected most functions B3GNT3 had, and list some proteins which have the same functions with B3GNT3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity | GCNT2,B3GNT2,B3GNT4,B3GNT1 |
| beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity | POMGNT1,B3GNT6 |
| galactosyltransferase activity | B4GALT4,B3GNT7,B3GNT4,B3GNT8,B3GNT7L,B3GNT2A,B3GNT5,B3GNTL1,GLT8D1,B4GALT5 |
Interacting Protein
B3GNT3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with B3GNT3 here. Most of them are supplied by our site. Hope this information will be useful for your research of B3GNT3.
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