Arfgap3
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Official Full Name
ADP-ribosylation factor GTPase activating protein 3 -
Overview
The protein encoded by this gene is a GTPase-activating protein (GAP) that associates with the Golgi apparatus and regulates the early secretory pathway of proteins. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1 (ARF1)-bound GTP, which is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is a prerequisite for the fusion of these vesicles with target compartments. The activity of this protein is sensitive to phospholipids. Multiple transcript variants encoding different isoforms have been found for this gene. This gene was originally known as ARFGAP1, but that is now the name of a related but different gene. [provided by RefSeq, Nov 2008] -
Synonyms
ARFGAP3;ADP-ribosylation factor GTPase activating protein 3;ARFGAP1;ADP-ribosylation factor GTPase-activating protein 3;ARF GAP 3;ADP-ribosylation factor GTPase activating protein 1
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- Cynomolgus
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- HEK293T
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
Arfgap3 involved in several pathways and played different roles in them. We selected most pathways Arfgap3 participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Arfgap3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | PARD6GB,CYTH1,VPS26BL,WIPF1A,CAV1,LDLRAP1B,ARPC5B,RHOAA,SRC,GIT2A |
Protein Function
Arfgap3 has several biochemical functions, for example, GTPase activator activity,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Arfgap3 itself. We selected most functions Arfgap3 had, and list some proteins which have the same functions with Arfgap3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activator activity | RGS5B,TBC1D4,ARHGAP40,TBC1D2,BCR,IQGAP3,ARHGAP32,SRGAP1,RGS12B,MURC |
| protein transporter activity | VPS35,XPO6,SNUPN,AP1S3,TNPO2,CHMP7,RUFY1,VPS26A,TMCO6,COG3 |
| metal ion binding | MOB3A,KEL,PPM1AB,ZFP653,APOA1BP,TRIM35-35,SFTPBB,LRP2,ACY3.1,ERCC2 |
| protein binding | NEUROG1,ZNF559,TRIM15,C9orf142,PARL,CBX1,LRRC4,TDGF1,IL1A,PHLPP1 |
Interacting Protein
Arfgap3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Arfgap3 here. Most of them are supplied by our site. Hope this information will be useful for your research of Arfgap3.
ZDHHC17;HTT;CD14;CXCL8;rbsB5;TRIM26
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References
- Wonderlich, ER; Leonard, JA; et al. ADP Ribosylation Factor 1 Activity Is Required To Recruit AP-1 to the Major Histocompatibility Complex Class I (MHC-I) Cytoplasmic Tail and Disrupt MHC-I Trafficking in HIV-1-Infected Primary T Cells. JOURNAL OF VIROLOGY 85:12216-12226(2011).
- Brown, MT; Andrade, J; et al. ASAP1, a phospholipid-dependent Arf GTPase-activating protein that associates with and is phosphorylated by Src. MOLECULAR AND CELLULAR BIOLOGY 18:7038-7051(1998).
