ATRX

  • Official Full Name

    alpha thalassemia/mental retardation syndrome X-linked

  • Overview

    The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.

  • Synonyms

    ATRX;alpha thalassemia/mental retardation syndrome X-linked;alpha thalassemia/mental retardation syndrome X linked (RAD54 (S. cerevisiae) homolog) , JMS, Juberg Marsidi syndrome , RAD54;transcriptional regulator ATRX;RAD54 homolog (S. cerevisiae);XH

Recombinant Proteins

  • Human
  • Zebrafish
  • Mouse
  • E.coli
  • Wheat Germ
  • Mammalian Cells
  • In Vitro Cell Free System
  • HEK293
  • GST
  • His
  • Non
  • His&SUMO
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
ATRX-10065H Recombinant Human ATRX, GST-tagged E.coli Human GST 1-87a.a.
ATRX-10066H Recombinant Human ATRX protein, His-tagged E.coli Human His 1-87aa
ATRX-1028H Recombinant Human ATRX protein, GST-tagged Wheat Germ Human GST
ATRX-10922Z Recombinant Zebrafish ATRX Mammalian Cells Zebrafish His
ATRX-150H Recombinant Human ATRX protein, GST-tagged Wheat Germ Human GST 1 a.a. - 90 a.a.
ATRX-2191M Recombinant Mouse ATRX Protein Mammalian Cells Mouse His
ATRX-150HCL Recombinant Human ATRX cell lysate Human Non
aTRX-1288H Recombinant Human aTRX protein, His-tagged E.coli Human His Trp221~Ser342
ATRX-1289H Recombinant Human ATRX protein, His-SUMO-tagged E.coli Human His&SUMO Trp221~Ser342
ATRX-13HFL Recombinant Full Length Human ATRX Protein, C-His-tagged E.coli Human His Full L.
ATRX-1535HF Recombinant Full Length Human ATRX Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 90 amino acids
ATRX-898M Recombinant Mouse ATRX Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
ATRX-898M-B Recombinant Mouse ATRX Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    ATRX involved in several pathways and played different roles in them. We selected most pathways ATRX participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ATRX were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    Protein Function

    ATRX has several biochemical functions, for example, ATP binding,DNA binding,DNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATRX itself. We selected most functions ATRX had, and list some proteins which have the same functions with ATRX. You can find most of the proteins on our site.

    Function Related Protein
    DNA translocase activity FBXO18,RAD54B
    DNA helicase activity FBXO18,SUPV3L1,DNA2,WRN,PEO1,MCM3,MCM3L,IGHMBP2,RUVBL2,RECQL
    chromatin binding SKOR2,URI1,HOXC13,NR5A2,WDR82,PROP1,ING5,ZMYND11,BRD3,MBD1
    methylated histone binding SPIN1,SUZ12,FAM156A,RRP8,GLYR1,ZMYND11,PHF1,TDRD3,MTF2,CCDC101
    histone binding CTSL2,PIH1D1,Ctsl,PRKCB,SART3,HIST1H4A,HIST2H4,HAT1,RBBP4,NPM1
    zinc ion binding TRAF2,TK1,BSPRY,AGBL3,ZDHHC19,BRCA1,CA5B,UQCRC2B,RNF40,CBLL1
    ATP binding OLA1,CARS,DNAJA3,SBK1,ERCC6L,MMAB,XRCC2,PINK1,MCM5,MAP2K2A
    chromo shadow domain binding SP100,NIPBL,TRIM28,CHAF1A,LBR
    DNA binding ZNF726,KCNH7,CROP,NR5A1B,HOXC12,HOXB2,DHX58,ZNF80,PQBP1,ZNF786

    Interacting Protein

    ATRX has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATRX here. Most of them are supplied by our site. Hope this information will be useful for your research of ATRX.

    DAXX;Mecp2;RAD50;EZH2

    Resources

    Research Area

    Tumor Suppressors

    References

    • Cryan, JB; Haidar, S; et al. Clinical multiplexed exome sequencing distinguishes adult oligodendroglial neoplasms from astrocytic and mixed lineage gliomas. ONCOTARGET 5:8083-8092(2014).
    • Su, ZL; Boersma, MD; et al. ChIP-less analysis of chromatin states. EPIGENETICS & CHROMATIN 7:-(2014).

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