ATR
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Official Full Name
Anthrax Toxin Receptor -
Overview
This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. -
Synonyms
ANTXR1;ATR;TEM8;FLJ10601;FLJ11298;FLJ21776;anthrax toxin receptor 1;OTTHUMP00000159975;OTTHUMP00000202140;OTTHUMP00000202171;tumor endothelial marker 8;2310008J16Rik;2810405N18Rik;anthrax toxin receptor;tumor endothelial marker 8 precursor
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ATR-1026H | Recombinant Human ATR protein, GST-tagged | Wheat Germ | Human | GST |
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| ATR-1136H | Recombinant Human ATR Protein (Ala2353-Met2644), N-His tagged | E.coli | Human | His | Ala2353-Met2644 |
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| ATR-1768H | Recombinant Human ATR protein, His & T7-tagged | E.coli | Human | His&T7 | Ala2353~Met2644 |
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| ATR-4932H | Recombinant Human ATR Protein, GST-tagged | Insect cells | Human | GST | 2245-end a.a. |
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Involved Pathway
ATR involved in several pathways and played different roles in them. We selected most pathways ATR participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ATR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
ATR has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ATR itself. We selected most functions ATR had, and list some proteins which have the same functions with ATR. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
ATR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATR here. Most of them are supplied by our site. Hope this information will be useful for your research of ATR.
ATR Related Signal Pathway
Resources
Research Area
Tumor SuppressorsEndothelial Cell Development Molecules
Endothelial Cell Markers
Histone Phosphorylation
p53 Pathway
G1 (Restriction) Checkpoints
G2/M (DNA Damage) Checkpoints
Related Services
Related Products
References
- Huebner, M; Ben Haddada, M; et al. Layer-by-layer generation of PEG-based regenerable immunosensing surfaces for small-sized analytes. BIOSENSORS & BIOELECTRONICS 67:334-341(2015).
- Chen, HH; Hsiao, YC; et al. In situ fabrication of cleavable peptide arrays on polydimethylsiloxane and applications for kinase activity assays. ANALYTICA CHIMICA ACTA 865:53-59(2015).
