ATP6V0B
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Official Full Name
ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -
Overview
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c, c, and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is part of the transmembrane V0 domain and is the human counterpart of yeast VMA16. Two alternatively spliced transcript variants that encode different proteins have been found for this gene. -
Synonyms
ATP6V0B;ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b;ATP6F, ATPase, H+ transporting, lysosomal (vacuolar proton pump) 21kD , ATPase, H+ transporting, lysosomal 21kDa, V0 subunit c;V-type proton ATPase 21 kDa proteolipid subunit;HATPL;VMA16;ATP6F;V-ATPase 21 kDa proteolipid subunit;Vacuolar proton pump 21 kDa proteolipid subunit;VATO_HUMAN;V-ATPase subunit c;vacuolar proton pump, 21 kDa subunit;H(+)-transporting two-sector ATPase, subunit F;vacuolar ATP synthase 21 kDa proteolipid subunit
Recombinant Proteins
- Rhesus macaque
- Chicken
- Zebrafish
- Human
- Bovine
- Mus musculus
- Mammalian Cells
- HEK293
- E.coli
- His
- Non
- His&Fc&Avi
Involved Pathway
ATP6V0B involved in several pathways and played different roles in them. We selected most pathways ATP6V0B participated on our site, such as Oxidative phosphorylation,Metabolic pathways,Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP6V0B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Epithelial cell signaling in Helicobacter pylori infection | IL-8,PLCG2,JAM2,ATP6V1F,ATP6V0D2,ATP6V1C2,ATP6V0A1,NFKB1,TJP1,RELA |
| Tuberculosis | TRADD,AKT2,ITGAM,MYD88,FCGR1A,PLK3,CARD9,FCGR3A,CALM1,IFNA21 |
| Vibrio cholerae infection | PRKACG,ATP6V1C2,ATP6V1D,ATP6V0A4,ATP6V1G2,ATP6V1B2,ATP6V1H,ATP6V1G1,PDIA4,PLCG1 |
| Phagosome | FCGR3B,ITGB2,RAB7,C1R,HLA-A,ATP6V1BA,ATP6V1H,STX18,MPO,MSR1 |
| Metabolic pathways | PNP5A,CNDP1,PYGL,MTMR4,ACLYA,IPPK,ADC,AHCY,POLR3C,UGT2A1 |
| Rheumatoid arthritis | TNF,Il23a,CCL3,HLA-DPA1,CD28,HLA-DOB,ATP6V0D1,Ctsl,ATP6V0A1,CXCL5 |
| Synaptic vesicle cycle | ATP6V0A1,ATP6V0C,SLC17A7,SLC18A2,ATP6V1E1,STXBP1,SLC18A1,NSF,SLC17A8,UNC13C |
| Oxidative phosphorylation | COX5A,ATP6V1G3,ATP5L,SDHA,ATP5H,ATP6V0CB,NDUFS2,UQCRQ,Atp5g2,ATP6V1G1 |
| Lysosome | GAA,SUMF1,AGA,SORT1A,SGSH,AP3M1,ARSA,LAMP3,SMPD1,CTSK |
Protein Function
ATP6V0B has several biochemical functions, for example, proton-transporting ATPase activity, rotational mechanism,transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP6V0B itself. We selected most functions ATP6V0B had, and list some proteins which have the same functions with ATP6V0B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| proton-transporting ATPase activity, rotational mechanism | ATP6AP1B,ATP6V1C1,ATP5D,ATP6V0CA,ATP6V1AA,ATP6V0A2B,TCIRG1,ATP6V0A1,ATP6V0C,ATP6V0A1B |
| transporter activity | SLC5A6B,CRABP2B,SLCO1A6,OCA2,STEAP1,TAP2,SLCO1B2,RBP2A,APODA.2,AQP3 |
Interacting Protein
ATP6V0B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP6V0B here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP6V0B.
FAS;YWHAG;IRAK3
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