ATP1B4
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Official Full Name
ATPase, Na+/K+ transporting, beta 4 polypeptide -
Overview
This gene has been found in all vertebrate genomes sequenced to date. However, this gene has undergone a change in function in placental mammals compared to other species. Specifically, in fish, avian, and amphibian species, this gene encodes plasma membrane-bound beta-subunits of Na,K-ATPase. In placental mammals, the encoded protein interacts with the nuclear transcriptional coregulator SKIP and may be involved in the regulation of TGF-beta signaling. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ATP1B4;ATPase, Na+/K+ transporting, beta 4 polypeptide;ATPase, (Na+)/K+ transporting, beta 4 polypeptide;protein ATP1B4;X,K-ATPase beta-m subunit;x/potassium-transporting ATPase subunit beta-m
Recombinant Proteins
- Mouse
- Chicken
- Rat
- Human
- Sus scrofa (Pig)
- Mus musculus
- Bovine
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- E.coli
- His
- Non
- His&T7
- Myc&DDK
- His&Fc&Avi
Involved Pathway
ATP1B4 involved in several pathways and played different roles in them. We selected most pathways ATP1B4 participated on our site, such as cGMP-PKG signaling pathway,cAMP signaling pathway,Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP1B4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| cGMP-PKG signaling pathway | NPR2,SLC25A31,CREB3L2,GNAQ,GTF2IRD1,ATP1A3,PPP3CC,PIK3CG,ATP1A4,PIK3R1 |
| Gastric acid secretion | CALM3,PRKACA,CAMK2D,CALM4,HRH2,ATP1A1,PLCB4,CAMK2A,GNAI3,PRKACB |
| Thyroid hormone synthesis | PLCB2,GPX8,HSPA5,PRKCG,GPX5,TPO,PRKCA,ITPR1,FXYD2,CREB3L3 |
| Protein digestion and absorption | COL24A1,SLC1A1,COL7A1,COL15A1,PRSS2,ATP1B3,CELA2A,CPB2,COL27A1,SLC8A1 |
| Pancreatic secretion | CLCA2,RHOA,CPB2,SCTR,PRKCA,RAB8A,PLCB4,CLCA1,PLA2G3,PLA2G5 |
| Cardiac muscle contraction | COX5AA,CACNG7A,COX8C,COX7B2,UQCRH,MYH15,COX5B,CACNG1A,ATP1B2,COX6A1 |
| Aldosterone-regulated sodium reabsorption | INS1,INS,ATP1B3,FXYD2,KCNJ1,SFN,NR3C2,PIK3CA,PRKCG,SCNN1G |
| cAMP signaling pathway | FFAR2,FXYD1,VIPR2,BAD,RAF1,GHRL,PDE3A,GRIN3B,PIK3CA,CALML5 |
| Salivary secretion | ATP1A2,LYZ2,ATP1A1,PLCB2,ATP1B1,PLCB4,LPO,AQP5,STATH,PLCB1 |
Protein Function
ATP1B4 has several biochemical functions, for example, monovalent inorganic cation transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP1B4 itself. We selected most functions ATP1B4 had, and list some proteins which have the same functions with ATP1B4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
ATP1B4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP1B4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP1B4.
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References
- Gao, K; Song, Z; et al. Genetic analysis of the ATP1B4 gene in Chinese Han patients with Parkinson's disease. MOLECULAR BIOLOGY REPORTS 41:2307-2311(2014).
- Sarkozy, M; Zvara, A; et al. Metabolic syndrome influences cardiac gene expression pattern at the transcript level in male ZDF rats. CARDIOVASCULAR DIABETOLOGY 12:-(2013).
