ATF6B

  • Official Full Name

    activating transcription factor 6 beta
  • Overview

    The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    ATF6B;activating transcription factor 6 beta;cAMP responsive element binding protein like 1 , CREBL1;cyclic AMP-dependent transcription factor ATF-6 beta;G13;G13 protein;ATF 6 beta;ATF6-beta;ATF6B_HUMAN;ATF6beta;cAMP response element binding protein related protein;cAMP response element-binding protein-related protein;cAMP responsive element binding protein like 1;cAMP-dependent transcription factor ATF-6 beta;cAMP-responsive element-binding protein-like 1;CREB L1;Creb related protein;CREB RP;Creb-rp;CREBL 1;CREBL1;Crebrp;Cyclic AMP dependent transcription factor ATF 6 beta;Cyclic AMP dependent transcription factor ATF6 beta;FLJ10066;OTTHUMP00000029432;OTTHUMP00000029433;Processed cyclic AMP-dependent transcription factor ATF-6 beta;Protein G13;Creb-related protein;cAMP responsive element binding protein-like 1

Recombinant Proteins

  • Human
  • Mouse
  • Zebrafish
  • Mus musculus
  • E.coli
  • Mammalian Cell
  • Wheat Germ
  • In Vitro Cell Free System
  • HEK293
  • E.coli expression system
  • GST
  • His
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
ATF6B-9965H Recombinant Human ATF6B, GST-tagged E.coli Human GST 1-318a.a.
ATF6B-2070M Recombinant Mouse ATF6B Protein Mammalian Cell Mouse His
ATF6B-26100TH Recombinant Human ATF6B Protein, GST-tagged Wheat Germ Human GST 1 a.a. - 318 a.a.
ATF6B-26189TH Recombinant Human ATF6B Wheat Germ Human Non 87 amino acids
ATF6B-4821Z Recombinant Zebrafish ATF6B Mammalian Cell Zebrafish His
ATF6B-1520HF Recombinant Full Length Human ATF6B Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 318 amino acids
ATF6B-816M Recombinant Mouse ATF6B Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
ATF6B-816M-B Recombinant Mouse ATF6B Protein Pre-coupled Magnetic Beads HEK293 Mouse
RFL-9388MF Recombinant Full Length Mouse Cyclic Amp-Dependent Transcription Factor Atf-6 Beta(Atf6B) Protein, His-Tagged E.coli expression system Mus musculus His Full L. Full Length of Mature Protein (2-699)

    Involved Pathway

    ATF6B involved in several pathways and played different roles in them. We selected most pathways ATF6B participated on our site, such as Adrenergic signaling in cardiomyocytes,Alcoholism,Aldosterone synthesis and secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATF6B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Dopaminergic synapse GNG7,TH,MAPK9,PPP2R2C,PPP2CA,PPP2CB,MAPK8,PRKCB,CALY,CREB5
    Aldosterone synthesis and secretion GNAS,HSD3B4,CAMK2B,PRKCE,PRKD3,PRKD1,PLCB3,PRKCA,NETO2,CALM2
    G1 to S cell cycle control TFDP1B,MYT1,E2F6,CDKN1C
    Alcoholism H2AFY2,GM14483,CREB5,GNGT2,HIST1H4F,DRD1A,H3F3C,HIST1H4J,HIST1H2BC,HDAC6
    Adrenergic signaling in cardiomyocytes ATP1A1,CACNA1C,CACNG3,CREB5,AKT3A,CREB3,KCNE1,PPP2CA,CALM4,ATP1A2
    Cocaine addiction TH,CREB5,GRIN2B,BDNF,SLC18A2,GNAI3,SLC6A3,GRIN2C,GRIA2,GRIN1
    Estrogen signaling pathway FKBP4,AKT1,SHC1,SOS1,HSPA8,GNAI2,ITPR3,HSPA2,MMP9,CALM3

    Protein Function

    ATF6B has several biochemical functions, for example, cAMP response element binding,protein binding,sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATF6B itself. We selected most functions ATF6B had, and list some proteins which have the same functions with ATF6B. You can find most of the proteins on our site.

    Function Related Protein
    cAMP response element binding E4F1,CREB3L3L,CREB3L2,CREB1,ATF2,CREB3L3,CREB3L4,CREB3L1,ATF6,CREB3
    transcription regulatory region DNA binding SMAD7,KCNA3,NKX3,FOXA3,HDAC1,GABPB2,FOXI1,CTCF,PAX2,PRDM5
    sequence-specific DNA binding ZNF394,GCM2,ARNTL,VENT,LHX2B,CEBP1,LHX3,JUNBB,PAX6B,BCL2
    transcription factor activity, sequence-specific DNA binding BLF,FOXP1B,TBX6,NKX2,IKZF4,RUNX1T1,FOXA2,KLF6,ELF1,NR1H5
    protein binding CCK,TMED1,ZFP523,CEP170L,SIX3,SIK2,RB1,CDKN2C,TACSTD2,TAF3

    Interacting Protein

    ATF6B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATF6B here. Most of them are supplied by our site. Hope this information will be useful for your research of ATF6B.

    p27958-pro_0000037575;CDK6;ysuB;proP16;proP17

    Resources

    References

    • Maganti, A; Evans-Molina, C; et al. From immunobiology to beta-cell biology The changing perspective on type 1 diabetes. ISLETS 6:-(2014).
    • Osborne, B; Yao, TW; et al. A rare variant in human fibroblast activation protein associated with ER stress, loss of enzymatic function and loss of cell surface localisation. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 1844:1248-1259(2014).

    Ask a Question for All ATF6B Products

    Required fields are marked with *

    My Review for All ATF6B Products

    Required fields are marked with *