ASL
-
Official Full Name
argininosuccinate lyase -
Overview
This gene encodes a member of the lyase 1 family. The encoded protein forms a cytosolic homotetramer and primarily catalyzes the reversible hydrolytic cleavage of argininosuccinate into arginine and fumarate, an essential step in the liver in detoxifying ammonia via the urea cycle. Mutations in this gene result in the autosomal recessive disorder argininosuccinic aciduria, or argininosuccinic acid lyase deficiency. A nontranscribed pseudogene is also located on the long arm of chromosome 22. Alternatively spliced transcript variants encoding different isoforms have been described. -
Synonyms
ASL;argininosuccinate lyase;Argininosuccinase;Arginosuccinase;ARLY_HUMAN;ASAL;EC 4.3.2.1
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rat
- E.coli
- HEK293
- Mammalian Cell
- Human
- E.Coli or Yeast
- Insect Cell
- Wheat Germ
- Insect Cells
- In Vitro Cell Free System
- Mammalian cells
- HEK293T
- GST
- His
- Myc&DDK
- Non
- His&GST
- Flag
- His&Fc&Avi
Involved Pathway
ASL involved in several pathways and played different roles in them. We selected most pathways ASL participated on our site, such as Arginine biosynthesis,Alanine, aspartate and glutamate metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ASL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Alanine, aspartate and glutamate metabolism | ASL2,GLUD1A,GOT1,ybaS,GFPT2,GLULA,GPT,IL4I1,GLUD2,AGXT |
| Metabolic pathways | POLR3F,CDS2,HSD3B4,CKB,ENO1B,SLC33A1,HMGCR,ST6GALNAC1,TPH1,PNPLA3 |
| Biosynthesis of amino acids | ENO1B,ALDOA,PKLR,TKTB,ARG2,ALDH18A1,ENO3,MAT2AL,SHMT2,ENO2 |
| Arginine biosynthesis | GOT2,GOT2B,GLUD1,GLS,NOS2B,ASS1,NOS2A,GOT1,GLS2,NOS2 |
Protein Function
ASL has several biochemical functions, for example, argininosuccinate lyase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ASL itself. We selected most functions ASL had, and list some proteins which have the same functions with ASL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| argininosuccinate lyase activity | ASL2 |
| protein binding | RALB,PPP2CA,NIPAL1,CREB3L1,SH2D1B,DTX3,EPHA2,NSMCE1,APBB3,OSBP |
Interacting Protein
ASL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ASL here. Most of them are supplied by our site. Hope this information will be useful for your research of ASL.
WDYHV1;FBP1;HMOX1;CSNK2A2;OVGP1;QARS
Resources
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References
- Curcio, F; Villano, G; et al. Epidemiological Survey of Hepatitis C Virus Infection in a Cohort of Patients From a Ser.T in Naples, Italy. JOURNAL OF ADDICTION MEDICINE 5:43-49(2011).
- Reuter, S; Oette, M; et al. Prevalence and characteristics of hepatitis B and C virus infections in treatment-na < ve HIV-infected patients. MEDICAL MICROBIOLOGY AND IMMUNOLOGY 200:39-49(2011).
