ARSG
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Official Full Name
arylsulfatase G -
Overview
Sulfatases, such as ARSG, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules. This gene, a novel arylsulfatase, has activity toward pseudosubstrates including p-nitrocatechol sulfate and 4-methylumbelliferyl sulfate. Activity is competitively inhibited by phosphate. The unprocessed protein is active as a 63-kDa monomer and demonstrates an acidic pH optimum as typically seen for lysosomal sulfatases. The protein accumulates within lysosomes and is also a glycoprotein that binds specifically to mannose 6-phosphate receptors. -
Synonyms
ARSG;arylsulfatase G;KIAA1001;ARSG_HUMAN;Arylsulfatase G precursor;ASG;PRO1777;UNQ839
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rat
- E.coli
- CHO
- Mammalian Cell
- Wheat Germ
- In Vitro Cell Free System
- HEK293T
- Mammalian cells
- HEK293
- GST
- His
- Non
- Myc&DDK
- Flag
- His&SUMO
- His&Fc&Avi
Involved Pathway
ARSG involved in several pathways and played different roles in them. We selected most pathways ARSG participated on our site, such as Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARSG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Lysosome | SGSH,ATP6V0A1B,SORT1,LITAF,SORT1B,NAGA,AP4S1,NAGPA,NEU1,ATP6V1H |
Protein Function
ARSG has several biochemical functions, for example, arylsulfatase activity,NOT arylsulfatase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARSG itself. We selected most functions ARSG had, and list some proteins which have the same functions with ARSG. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| arylsulfatase activity | ARSE,ARSK,ARSB,SULF1,ARSD,ARSI,ARSJ,ARSA,SULF2,ARSH |
| metal ion binding | ZFP422,ADSSL,MGRN1A,DDX11,KDM6BB,PRKCBB,NT5DC1,ATP2B1B,ZNF503,PDE7B |
Interacting Protein
ARSG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARSG here. Most of them are supplied by our site. Hope this information will be useful for your research of ARSG.
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References
- van Tilburg, MF; Rodrigues, MAM; et al. Membrane-associated proteins of ejaculated sperm from Morada Nova rams. THERIOGENOLOGY 79:1247-1261(2013).
- Bhattacharyya, S; Solakyildirim, K; et al. Cell-Bound IL-8 Increases in Bronchial Epithelial Cells after Arylsulfatase B Silencing due to Sequestration with Chondroitin-4-Sulfate. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 42:51-61(2010).
