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ARNT

  • Product List
  • Overview
  • Review / Q&A
  • Official Full Name

    aryl hydrocarbon receptor nuclear translocator
  • Overview

    The aryl hydrocarbon (Ah) receptor is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the Ah receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in translocation of the ligand-binding subunit only to the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound Ah receptor to xenobiotic responsive elements in the promoters of genes for these enzymes. This gene encodes a protein that forms a complex with the ligand-bound Ah receptor, and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1. A t(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia. Alternative splicing results in multiple transcript variants.
  • Synonyms

    ARNT;aryl hydrocarbon receptor nuclear translocator;bHLHe2;HIF 1beta;dioxin receptor, nuclear translocator;class E basic helix-loop-helix protein 2;hypoxia-inducible factor 1, beta subunit;HIF1B;TANGO;HIF1BETA;HIF-1beta;HIF1-beta;HIF-1-beta

  • Human
  • Zebrafish
  • Mouse
  • Chicken
  • Rat
  • Klebsiella Pneumoniae
  • Wheat Germ
  • Mammalian Cell
  • HEK293
  • Insect Cell
  • E.coli
  • Yeast
  • E.Coli or Yeast
  • Mamanlian cells
  • HEK293T
  • E.coli expression system
  • GST
  • His
  • Myc&DDK
  • His&S
  • His&T7
  • Non
  • Flag
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
ARNT-20H Recombinant Human ARNT, GST-tagged Wheat Germ Human GST
ARNT-1863Z Recombinant Zebrafish ARNT Mammalian Cell Zebrafish His
ARNT-18H Recombinant Human ARNT, MYC/DDK-tagged HEK293 Human Myc&DDK
ARNT-1961M Recombinant Mouse ARNT Protein Mammalian Cell Mouse His
ARNT-19H Recombinant Human ARNT, MYC/DDK-tagged HEK293 Human Myc&DDK
ARNT-288H Recombinant Human ARNT protein, GST-tagged Insect Cell Human GST
ARNT-32H Recombinant Human ARNT protein, His/S-tagged E.coli Human His&S
ARNT-33H Recombinant Human ARNT protein, His-tagged Yeast Human His 1-474 a.a.
Arnt-3647M Recombinant Mouse Arnt, His-tagged E.Coli or Yeast Mouse His 791
ARNT-3648H Recombinant Human ARNT, His-tagged E.Coli or Yeast Human His 773
ARNT-5774C Recombinant Chicken ARNT Mammalian Cell Chicken His
ARNT-794R Recombinant Rat ARNT Protein Mammalian Cell Rat His
ARNT-8057H Recombinant Human ARNT protein, His & T7-tagged E.coli Human His&T7 Gln624~Glu789
ARNT-8692HCL Recombinant Human ARNT 293 Cell Lysate HEK293 Human Non
arnT-01K Recombinant Klebsiella pneumoniae (strain 342) arnT protein, His-tagged E.coli Klebsiella Pneumoniae His 429-551aa
ARNT-0377H Recombinant Human ARNT Protein (Met1-Ser348), N-His-tagged E.coli Human His Met1-Ser348
ARNT-1433HFL Recombinant Full Length Human ARNT, Flag-tagged Mamanlian cells Human Flag Full L.
ARNT-1740H Recombinant Human ARNT Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
ARNT-3507H Recombinant Human ARNT Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
ARNT-450R Recombinant Rat ARNT Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
ARNT-450R-B Recombinant Rat ARNT Protein Pre-coupled Magnetic Beads HEK293 Rat
Arnt-648M Recombinant Mouse Arnt Protein, MYC/DDK-tagged HEK293T Mouse Myc&DDK
ARNT-744M Recombinant Mouse ARNT Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
ARNT-744M-B Recombinant Mouse ARNT Protein Pre-coupled Magnetic Beads HEK293 Mouse
RFL-1217HF Recombinant Full Length Human Aryl Hydrocarbon Receptor Nuclear Translocator(Arnt) Protein, His-Tagged E.coli expression system Human His Full L. Full Length of Mature Protein (2-789aa)

Involved Pathway

ARNT involved in several pathways and played different roles in them. We selected most pathways ARNT participated on our site, such as HIF- signaling pathway,Pathways in cancer,Chemical carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARNT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Renal cell carcinoma RAF1,EPAS1,PIK3CB,AKT1,FH,BRAF,EGLN2,PIK3CA,EP300,MET
Pathways in cancer FZD7,MDM2,CKS2,LAMB3,HGF,TRP53,FGF16,KRAS,Shh,F2RL3
HIF- signaling pathway NPPA,EPO,IFNGR1,ANGPT1,PIK3R1,IL6R,TIMP1,PRKCB,AKT1,TLR4
Chemical carcinogenesis GSTK1,NAT1,UGT1A9,ADH4,CHRNA7,CYP2C54,GSTA4,PTGS2,SULT1A3,MGST3

Protein Function

ARNT has several biochemical functions, for example, aryl hydrocarbon receptor activity,aryl hydrocarbon receptor binding,enhancer binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARNT itself. We selected most functions ARNT had, and list some proteins which have the same functions with ARNT. You can find most of the proteins on our site.

Function Related Protein
transcription factor activity, sequence-specific DNA binding INSM1A,YY1,ZSCAN4,ZNF773,DMRTC1C2,SOX11,DMRT2B,ZKSCAN1,ZNF550,FOXO1B
protein binding RABEP1,RPIA,SENP6,ELAVL2,SLC30A3,TMEM120B,NAT8B,SMG5,PCSK5,HLA-A
protein heterodimerization activity NPM1,SMAD3,SOX9,H2AFVB,BAXA,DLG4B,CAV1,MCL1B,SRY,HMG20A
aryl hydrocarbon receptor binding AIP,ARNT2,ARNTL
transcription coactivator activity MED23,CRSP7,APEX1,PCBD1,KAT6A,PDLIM1,JUND,SUPT7L,NFATC4,NR1I2
transcription factor binding TMEM173,MDFIC,MED25,EPAS1,SOX10,IFI203,ID1,HHEX,CTBP1,SOX17
aryl hydrocarbon receptor activity AHR2
enhancer binding RAI1,AHR,SOX9,TCF12,LEF1,TCF3,ELL3,TIPARP,FOXH1,SMAD3
contributes_to transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding HIF1A

Interacting Protein

ARNT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARNT here. Most of them are supplied by our site. Hope this information will be useful for your research of ARNT.

HIF1A;AHR;NCOA7;NCOR2;Clock;SMAD9

Resources

References

  • Basham, KJ; Leonard, CJ; et al. Dioxin Exposure Blocks Lactation through a Direct Effect on Mammary Epithelial Cells Mediated by the Aryl Hydrocarbon Receptor Repressor. TOXICOLOGICAL SCIENCES 143:36-45(2015).
  • Kurita, H; Schnekenburger, M; et al. The Ah Receptor Recruits IKK alpha to Its Target Binding Motifs to Phosphorylate Serine-10 in Histone H3 Required for Transcriptional Activation. TOXICOLOGICAL SCIENCES 139:121-132(2014).

Reviews

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