ARNT
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Official Full Name
aryl hydrocarbon receptor nuclear translocator -
Overview
The aryl hydrocarbon (Ah) receptor is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the Ah receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in translocation of the ligand-binding subunit only to the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound Ah receptor to xenobiotic responsive elements in the promoters of genes for these enzymes. This gene encodes a protein that forms a complex with the ligand-bound Ah receptor, and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1. A t(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia. Alternative splicing results in multiple transcript variants. -
Synonyms
ARNT;aryl hydrocarbon receptor nuclear translocator;bHLHe2;HIF 1beta;dioxin receptor, nuclear translocator;class E basic helix-loop-helix protein 2;hypoxia-inducible factor 1, beta subunit;HIF1B;TANGO;HIF1BETA;HIF-1beta;HIF1-beta;HIF-1-beta
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- Rat
- Klebsiella Pneumoniae
- Wheat Germ
- Mammalian Cells
- HEK293
- Insect Cells
- E.coli
- Yeast
- E.Coli/Yeast
- GST
- His
- DDK&Myc
- His&S
- His&T7
- Non
- Flag
- Avi&Fc&His
Involved Pathway
ARNT involved in several pathways and played different roles in them. We selected most pathways ARNT participated on our site, such as HIF- signaling pathway,Pathways in cancer,Chemical carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARNT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chemical carcinogenesis | NAT2,SULT2A1,GSTA5,UGT1A6,ALDH3B1,GSTM4,PTGS2,UGT1A7,ADH7,CYP2C19 |
| HIF- signaling pathway | INS2,CAMK2A,RPS6,MAPK3,HMOX1,EGLN1,LTBR,PIK3R3,PIK3R2,PDHB |
| Pathways in cancer | IKBKG,TCEB2,WNT3,F2RL3,EGLN1,ARNT2,CXCR4,FGF16,WNT2,TRAF4 |
| Renal cell carcinoma | MAPK3,MAP2K2,RAP1A,ARAF,PDGFB,TGFB2,TGFB1,ARNT2,TGFA,PAK7 |
Protein Function
ARNT has several biochemical functions, for example, aryl hydrocarbon receptor activity,aryl hydrocarbon receptor binding,enhancer binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARNT itself. We selected most functions ARNT had, and list some proteins which have the same functions with ARNT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription coactivator activity | CDK7,ARID1A,NR2F1,PMF1,NR1I2,IL31RA,TUBB3,GMEB2,JUPA,TAF9 |
| transcription factor activity, sequence-specific DNA binding | DBPB,CEBP1,RCAN1,SOX7,TFAM,ZFY2,BCL3,RXRBB,FOXH1,MYT1 |
| aryl hydrocarbon receptor binding | ARNT2,AIP,ARNTL |
| aryl hydrocarbon receptor activity | AHR2 |
| enhancer binding | SMAD2,MESP1,SMAD3,TCF3,SP1,ELL3,FOXH1,SOX9,LEF1,RAI1 |
| protein heterodimerization activity | MEF2A,CYBB,GAD2,APITD1,P4HB,SNX1,GABPB1,KCNB1,PIK3R2,TOP2B |
| protein binding | HYAL3,NPHS1,C1orf216,DGCR6L,CRYBB3,PARP2,GALR1,CORO1C,NEDD4L,PACSIN3 |
| contributes_to sequence-specific DNA binding | FIGLA,SMAD4,HDAC4,HNRNPAB,EPAS1,TRIM28,NEUROD1,PPARG,TCF3,HIF1A |
| transcription factor binding | LEF1,HES4,NKX2-5,TRERF1,RBPJ,CDK9,EGR1,CXXC5,NCOA2,MED12 |
Interacting Protein
ARNT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARNT here. Most of them are supplied by our site. Hope this information will be useful for your research of ARNT.
HIF1A;AHR;NCOA7;NCOR2;Clock;SMAD9
Resources
Research Area
Transcription Factors in the Akt PathwayIntracellular Signaling Molecules in Angiogenesis
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References
- Basham, KJ; Leonard, CJ; et al. Dioxin Exposure Blocks Lactation through a Direct Effect on Mammary Epithelial Cells Mediated by the Aryl Hydrocarbon Receptor Repressor. TOXICOLOGICAL SCIENCES 143:36-45(2015).
- Kurita, H; Schnekenburger, M; et al. The Ah Receptor Recruits IKK alpha to Its Target Binding Motifs to Phosphorylate Serine-10 in Histone H3 Required for Transcriptional Activation. TOXICOLOGICAL SCIENCES 139:121-132(2014).
