ARMET
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Official Full Name
MANF mesencephalic astrocyte-derived neurotrophic factor -
Overview
The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and promotes cell proliferation. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of polymorphisms in the arginine-rich region, including a specific mutation that changes the previously numbered codon 50 from ATG to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus not tumor-related. -
Synonyms
ARP;ARMET;MGC142148;MGC142150;mesencephalic astrocyte-derived neurotrophic factor;OTTHUMP00000210954;arginine-rich, mutated in early stage tumors
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Involved Pathway
ARMET involved in several pathways and played different roles in them. We selected most pathways ARMET participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ARMET were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
ARMET has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ARMET itself. We selected most functions ARMET had, and list some proteins which have the same functions with ARMET. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
ARMET has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARMET here. Most of them are supplied by our site. Hope this information will be useful for your research of ARMET.
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References
- Wang, HP; Ke, ZJ; et al. Spatiotemporal Expression of MANF in the Developing Rat Brain. PLOS ONE 9:-(2014).
- Lindahl, M; Danilova, T; et al. MANF Is Indispensable for the Proliferation and Survival of Pancreatic beta Cells. CELL REPORTS 7:366-375(2014).
