ARID4A
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Official Full Name
AT rich interactive domain 4A (RBP1-like) -
Overview
The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described. -
Synonyms
ARID4A;AT rich interactive domain 4A (RBP1-like);RBBP1, retinoblastoma binding protein 1;AT-rich interactive domain-containing protein 4A;RBP 1;RBP1;AT rich interactive domain containing protein 4A;ARID 4A;ARID domain containing protein 4A;AT rich interactive domain 4A;RBBP 1;RBBP1;RBP1 like;OTTHUMP00000179023;OTTHUMP00000179024;OTTHUMP00000197517;retinoblastoma binding protein 1;retinoblastoma-binding protein 1;ARID domain-containing protein 4A;RBP-1;RBBP-1
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ARID4A-2117C | Recombinant Chicken ARID4A | Mammalian Cell | Chicken | His |
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| ARID4A-3363Z | Recombinant Zebrafish ARID4A | Mammalian Cell | Zebrafish | His |
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| ARID4A-3680H | Recombinant Human ARID4A, His-tagged | E.Coli or Yeast | Human | His | 1257 |
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| ARID4A-797H | Recombinant Human ARID4A protein, GST-tagged | Wheat Germ | Human | GST |
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Involved Pathway
ARID4A involved in several pathways and played different roles in them. We selected most pathways ARID4A participated on our site, such as Chromatin modifying enzymes,Chromatin organization,HDACs deacetylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARID4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HDACs deacetylate histones | SAP30L,HMG20B,SAP30,MTA1,BRMS1,GATAD2B,GATAD2AB,MBD3,GATAD2A,ANO9A |
| Chromatin organization | TADA1,PADI4,SMARCB1B,KDM3B,KANSL3,VPS72,RBB4L,MCRS1,CCDC101,KDM6B |
| Chromatin modifying enzymes | HIST2H3C,MCRS1,SAP18,DNMT3A,SMYD2,ING5,EPC1,PRMT5,BRMS1,MSL2B |
Protein Function
ARID4A has several biochemical functions, for example, DNA binding,transcription factor activity, sequence-specific DNA binding,transcription regulatory region DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARID4A itself. We selected most functions ARID4A had, and list some proteins which have the same functions with ARID4A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription regulatory region DNA binding | WT1,FOXC1,H2AFY,EGR2,CTCFL,NFE2L2,ZFP382,THRA,KLF4,TOMM20A |
| transcription factor activity, sequence-specific DNA binding | SOX11B,FOXO1A,REST,CBL,ZBTB48,LEF1,NFAT5A,AHR,SMAD7,TADA2A |
| DNA binding | ZNF124,ZNF155,STAT1B,PHC2,ZFP82,SIX4,ZNF711,ZFP513,CHD4A,FOXD1L |
Interacting Protein
ARID4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARID4A here. Most of them are supplied by our site. Hope this information will be useful for your research of ARID4A.
DEDD;BRMS1;q9rn24_bacan;SAP30;HDAC1
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References
- Fouz, N; Amid, A; et al. Gene Expression Analysis in MCF-7 Breast Cancer Cells Treated with Recombinant Bromelain. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 173:1618-1639(2014).
- Cajuso, T; Hanninen, UA; et al. Exome sequencing reveals frequent inactivating mutations in ARID1A, ARID1B, ARID2 and ARID4A in microsatellite unstable colorectal cancer. INTERNATIONAL JOURNAL OF CANCER 135:611-623(2014).
