ARHGEF3
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Official Full Name
Rho guanine nucleotide exchange factor (GEF) 3 -
Overview
Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ARHGEF3;Rho guanine nucleotide exchange factor (GEF) 3;rho guanine nucleotide exchange factor 3;DKFZP434F2429;exchange factor found in platelets and leukemic and neuronal tissues;XPLN;GEF3;RhoGEF protein;STA3;59.8 kDA protein;ARHGEF 3;Exchange factor found in platelets and leukemic and neuronal tissues XPLN;FLJ98126;GEF 3;MGC118905;STA 3;exchange factor found in platelets and leukemic and neuronal tissues, XPLN
Recombinant Proteins
- Mouse
- Chicken
- Zebrafish
- Human
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ARHGEF3-1898M | Recombinant Mouse ARHGEF3 Protein | Mammalian Cell | Mouse | His |
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| ARHGEF3-2308C | Recombinant Chicken ARHGEF3 | Mammalian Cell | Chicken | His |
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| ARHGEF3-5258Z | Recombinant Zebrafish ARHGEF3 | Mammalian Cell | Zebrafish | His |
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| ARHGEF3-786H | Recombinant Human ARHGEF3 protein, GST-tagged | Wheat Germ | Human | GST |
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| ARHGEF3-8731HCL | Recombinant Human ARHGEF3 293 Cell Lysate | HEK293 | Human | Non |
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| ARHGEF3-1238HF | Recombinant Full Length Human ARHGEF3 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 324 amino acids |
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| ARHGEF3-697M | Recombinant Mouse ARHGEF3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| ARHGEF3-697M-B | Recombinant Mouse ARHGEF3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
ARHGEF3 involved in several pathways and played different roles in them. We selected most pathways ARHGEF3 participated on our site, such as Cell death signalling via NRAGE, NRIF and NADE,G alpha (12/13) signalling events,GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GPCR downstream signaling | RLN2,GPR132,ADORA1,PIK3R6,CYSLTR1,ADRA2A,OR2AP1,EDN3,PROKR2,GPR55 |
| NRAGE signals death through JNK | ARHGEF9,ARHGEF16,ARHGEF18,AATF,DCLRE1B,FGD4,FGD2,AKAP13,NET1,ARHGAP4 |
| G alpha (12/13) signalling events | TRIO,AKAP13,GNA13,ARHGAP4A,ECT2,OBSCN,DCLRE1B,NET1,RHOGA,KALRN |
| Cell death signalling via NRAGE, NRIF and NADE | NET1,KALRNB,DCLRE1B,ARHGEF16,TIAM2,BCL2L11,CASP2,MCF2L,KALRN,TRIO |
| Rho GTPase cycle | RHOUA,STARD8,ARAP2,ARHGEF16,RHOT1A,ARHGEF17,NET1,RHOT1B,ARAP1,ARHGAP26 |
| Signal Transduction | STRA6,NPSR1,GPR132B,FAM123B,EMR3,PROK2,SKI,PTPRK,PRC1B,WDR19 |
| Regulation of RhoA activity | ARAP1,ARHGEF10,ARHGEF28,DEF6,NET1,PLEKHG6,ECT2,DLC1,ARHGAP4,ARHGEF18 |
| Signaling by GPCR | TAC2,RGS20,PTHLH,ARHGEF18A,CCRL2,ADM2,GPR55,TAS2R3,OXGR1A.2,MLN |
Protein Function
ARHGEF3 has several biochemical functions, for example, Rho guanyl-nucleotide exchange factor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF3 itself. We selected most functions ARHGEF3 had, and list some proteins which have the same functions with ARHGEF3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Rho guanyl-nucleotide exchange factor activity | VAV3B,TRIOA,FGD4,ARHGEF10,ALS2CL,FGD4A,PLEKHG2,ARHGEF28,FGD,SOS1 |
| protein binding | PDCD6IP,TDG,STK10,C2orf29,MTF1,FAM103A1,GTF2IRD2,H3F3A,SMARCAD1,SOX4 |
Interacting Protein
ARHGEF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF3.
TRIM27;TRIM23;CEP70
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