ARHGEF26
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Official Full Name
Rho guanine nucleotide exchange factor (GEF) 26 -
Overview
This gene encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. These proteins regulate Rho GTPases by catalyzing the exchange of GDP for GTP. The encoded protein specifically activates RhoG and plays a role in the promotion of macropinocytosis. Underexpression of the encoded protein may be a predictive marker of chemoresistant disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. -
Synonyms
ARHGEF26;Rho guanine nucleotide exchange factor (GEF) 26;rho guanine nucleotide exchange factor 26;DKFZP434D146;SGEF;Src homology 3 domain containing guanine nucleotide exchange factor;SH3 domain-containing guanine exchange factor;Src homology 3 do
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Involved Pathway
ARHGEF26 involved in several pathways and played different roles in them. We selected most pathways ARHGEF26 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF26 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
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Protein Function
ARHGEF26 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF26 itself. We selected most functions ARHGEF26 had, and list some proteins which have the same functions with ARHGEF26. You can find most of the proteins on our site.
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Interacting Protein
ARHGEF26 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF26 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF26.
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