ARAP1

  • Official Full Name

    ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

  • Overview

    The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.

  • Synonyms

    ARAP1;ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1;centaurin, delta 2 , CENTD2;arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1;ANK repeat and PH domain-containing protein 1;mKIAA0782;2410002L19Rik;ARAP 1;ARAP1_HUMAN;Arf GAPRho GAP ankyrin repeat and pleckstrin homology domains containing protein 1;Arf GAP Rho GAP ankyrin repeat and pleckstrin homology domain containing protein 1;Arf-GAP with Rho-GAP domain;CENT D2;Centaurin delta 2;Centaurin delta2;Centaurin-delta-2;CENTD 2;CENTD2;Cnt d2;Cnt-d2;Cntd2;KIAA0782;MGC176140;OTTHUMP00000211458;OTTHUMP00000211459;OTTHUMP00000211460;OTTHUMP00000211461;OTTHUMP00000211462;OTTHUMP00000211463;centaurin, delta 2;ARF-GAP, RHO-GAP, anky
Cat.# Product name Source (Host) Species Tag Protein Length Price
ARAP1-1832M Recombinant Mouse ARAP1 Protein Mammalian Cell Mouse His
ARAP1-26993TH Recombinant Human ARAP1, His-tagged E.coli Human His 757-1133 a.a.
ARAP1-32H Recombinant Human ARAP1 protein, GST-tagged Wheat Germ Human GST 1-1205 a.a.
ARAP1-337HCL Recombinant Human ARAP1 cell lysate Human Non
ARAP1-655M Recombinant Mouse ARAP1 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
ARAP1-655M-B Recombinant Mouse ARAP1 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    ARAP1 involved in several pathways and played different roles in them. We selected most pathways ARAP1 participated on our site, such as Endocytosis,Regulation of RhoA activity,Rho GTPase cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Signal Transduction EMR1,PROKR1,STARD8,RARG,ADM2A,SPOPL,EMR3,TLE4,ARHGAP17A,CRABP2
    Regulation of RhoA activity ARHGEF10L,PLEKHG6,ARHGEF18,ARHGAP9,ARHGEF15,ARHGEF25,DEF6,MCF2L,ARHGAP4,ARHGEF28
    Rho GTPase cycle ARHGAP17,GMIP,RHOV,STARD8,ARHGAP4,ARHGAP28,TAGAP,TAGAP1,FAM13A,DEPDC1B
    Signaling by Rho GTPases CHN1,CHN2,ARHGAP17A,MYO9B,ARAP2,ARHGAP44,ARHGAP23,RHOT1B,TAGAP1,ARHGAP17
    Endocytosis VPS37B,CCDC53,RHOAA,WASLA,ARRB2B,DNAJC6,VPS37C,LDLR,BF2,CAV1

    Protein Function

    ARAP1 has several biochemical functions, for example, GTPase activator activity,metal ion binding,phosphatidylinositol-3,4,5-trisphosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARAP1 itself. We selected most functions ARAP1 had, and list some proteins which have the same functions with ARAP1. You can find most of the proteins on our site.

    Function Related Protein
    type 1 angiotensin receptor binding BDKRB2,AGT,TYK2,GNA13B,ARRB2,GNB1,JAK2,GNG3,GNA13A,GNA13
    metal ion binding GLIS1,PFAS,PDE6B,HRG,NOTCH1A,GMIP,ZNF18,ZC3HAV1,NEK5,KAT8
    protein binding ERBB2,ATP1B1,LDHB,PPARA,GSTA4,LBR,EYA4,ATP5O,RAD54L,EID1
    phosphatidylinositol-3,4,5-trisphosphate binding PIRT,ADAP2,AKT1,ZFYVE1,DAPP1,JPH2,MAPKAP1,PARD3,BTK,GBF1
    GTPase activator activity DEPDC1,LLGL1,TBC1D20,CDC42EP1B,TBC1D30,RACGAP1,SMAP1,RGS10,AGFG1,RAP1GAP2

    Interacting Protein

    ARAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARAP1.

    TNFRSF10A;XRCC6;p27958-pro_0000037576;TNFRSF10B;ARPC3;ARIH2;FGFR3;TAB1;pi3p;VCAM1;GRB2;SNW1;UBASH3B

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