APOC4
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Official Full Name
apolipoprotein C-IV -
Overview
This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is thought to play a role in lipid metabolism. Polymorphisms in this gene may influence circulating lipid levels and may be associated with coronary artery disease risk. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring downstream apolipoprotein C-II (APOC2) gene. -
Synonyms
APOC4;apolipoprotein C-IV;APO C4;Apo CIV;APOC 4;ApoC IV;Apolipoprotein C IV;apolipoprotein C4;APO-CIV;APOC-IV
Recombinant Proteins
- Human
- Mouse
- Wheat germ
- Rat
- Rabbit
- E.coli
- Mammalian Cell
- Wheat Germ
- E.Coli or Yeast
- Yeast
- HEK293F
- HEK293
- GST
- His
- His&GST
- Non
- His&B2M
- His&Fc&Avi
Involved Pathway
APOC4 involved in several pathways and played different roles in them. We selected most pathways APOC4 participated on our site, such as Statin Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with APOC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Statin Pathway | APOC1,CETP,PDIA2 |
Protein Function
APOC4 has several biochemical functions, for example, lipid transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by APOC4 itself. We selected most functions APOC4 had, and list some proteins which have the same functions with APOC4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| lipid transporter activity | APOF,APOA1A,APOD,APOBB.1,VTG5,GM2A,SLCO2A1,APOM,MTP,VTG1 |
Interacting Protein
APOC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APOC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of APOC4.
Resources
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References
- Hu, MA; Lui, SSH; et al. Pharmacogenetic analysis of lipid responses to rosuvastatin in Chinese patients. PHARMACOGENETICS AND GENOMICS 20:634-637(2010).
- Kim, E; Li, K; et al. Expression of apolipoprotein C-IV is regulated by Ku antigen/peroxisome proliferator-activated receptor gamma complex and correlates with liver steatosis. JOURNAL OF HEPATOLOGY 49:787-798(2008).
