APLF
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Official Full Name
aprataxin and PNKP like factor -
Overview
C2ORF13 is a component of the cellular response to chromosomal DNA single- and double-strand breaks (Iles et al., 2007;(PubMed 17353262)). -
Synonyms
APLF;aprataxin and PNKP like factor;C2orf13, chromosome 2 open reading frame 13;aprataxin and PNK-like factor;MGC47799;XRCC1-interacting protein 1;PNK and APTX-like FHA protein;aprataxin- and PNK-like factor;apurinic-apyrimidinic endonuclease APL
Recombinant Proteins
- Human
- Mouse
- Bovine
- Chicken
- E.coli
- Mammalian Cell
- Insect Cell
- HEK293
- E.Coli or Yeast
- Wheat Germ
- HEK293T
- In Vitro Cell Free System
- GST
- His
- Flag
- Myc&DDK
- Non
- His&Fc&Avi
Involved Pathway
APLF involved in several pathways and played different roles in them. We selected most pathways APLF participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with APLF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
APLF has several biochemical functions, for example, 3-5 exonuclease activity,DNA-(apurinic or apyrimidinic site) lyase activity,endodeoxyribonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by APLF itself. We selected most functions APLF had, and list some proteins which have the same functions with APLF. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA-(apurinic or apyrimidinic site) lyase activity | HMGA1-RS1,HMGA2,APEX2,HMGA1A,RPS3,HMGA1B,HMGA1,NTHL1,NEIL3,APEX1 |
| endodeoxyribonuclease activity | DNASE1,DNASE1L3,ZRANB3,MRE11A,DNASE1L1,MBD4,DNASE1L3L,ERCC4,ERCC5,RPS3 |
| protein binding | DFFA,ZBTB48,ZNF394,PRUNE,THY1,TAF3,FBP2,CCNL2,GRHL2,HPGDS |
| metal ion binding | PDE12,GM12824,ZNF230,RIOK1,CBS,SP1,CYP4V7,ITGA6,RNF11A,CTDSPL |
| 3-5 exonuclease activity | WRN,RAD9A,RAD9,REV3L,RAD9B,TREX1,POLE,ERI1,POLA1,MRE11A |
| nucleotide binding | HINT3,RPS24,ZNF143B,MSI2A,MAP2K2B,MYO5A,DAZL,ZFML,CLK2A,CSF1RA |
Interacting Protein
APLF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APLF here. Most of them are supplied by our site. Hope this information will be useful for your research of APLF.
XRCC1;XRCC4;XRCC5
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