APEH
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Official Full Name
N-acylaminoacyl-peptide hydrolase -
Overview
This gene encodes the enzyme acylpeptide hydrolase, which catalyzes the hydrolysis of the terminal acetylated amino acid preferentially from small acetylated peptides. The acetyl amino acid formed by this hydrolase is further processed to acetate and a free amino acid by an aminoacylase. This gene is located within the same region of chromosome 3 (3p21) as the aminoacylase gene, and deletions at this locus are also associated with a decrease in aminoacylase activity. The acylpeptide hydrolase is a homotetrameric protein of 300 kDa with each subunit consisting of 732 amino acid residues. It can play an important role in destroying oxidatively damaged proteins in living cells. Deletions of this gene locus are found in various types of carcinomas, including small cell lung carcinoma and renal cell carcinoma. -
Synonyms
APEH;N-acylaminoacyl-peptide hydrolase;D3F15S2, D3S48E, DNF15S2;acylamino-acid-releasing enzyme;acyl-peptide hydrolase;acylaminoacyl-peptidase;oxidized protein hydrolase;APH;OPH;AARE;ACPH;D3S48E;D3F15S2;DNF15S2;MGC2178
Recombinant Proteins
- Chicken
- Human
- Rat
- Rhesus macaque
- Zebrafish
- Mammalian Cell
- E.coli
- E.Coli or Yeast
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| APEH-2298C | Recombinant Chicken APEH | Mammalian Cell | Chicken | His |
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| APEH-26038TH | Recombinant Human APEH, His-tagged | E.coli | Human | His | 560-732 a.a. |
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| Apeh-3142R | Recombinant Rat Apeh, His-tagged | E.Coli or Yeast | Rat | His | 732 |
|
| APEH-352R | Recombinant Rhesus monkey APEH Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| APEH-676H | Recombinant Human APEH protein, GST-tagged | Wheat Germ | Human | GST |
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| APEH-9860Z | Recombinant Zebrafish APEH | Mammalian Cell | Zebrafish | His |
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| APEH-8798HCL | Recombinant Human APEH 293 Cell Lysate | HEK293 | Human | Non |
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| APEH-1108HF | Recombinant Full Length Human APEH Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 732 amino acids |
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| APEH-181R | Recombinant Rhesus Macaque APEH Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| APEH-181R-B | Recombinant Rhesus Macaque APEH Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| APEH-2527H | Recombinant Human APEH protein, His-tagged | E.coli | Human | His | 1-732aa |
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Involved Pathway
APEH involved in several pathways and played different roles in them. We selected most pathways APEH participated on our site, such as Eukaryotic Translation Termination,Gene Expression,Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with APEH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Translation | EIF5,EIF2B1,EEF1A2,EEF1B2,EEF1D,EEF1G |
| Eukaryotic Translation Termination | RPL35 |
| Metabolism of proteins | MUC20,COX17,DPH1,IGF2B,SEC22A,SERPINA7,DPP4,ADAMTS13,CNIH3,GALNT5 |
| Gene Expression | RNPC3,MADD,ZNF257,ZNF12,ZKSCAN5,ZNF729,TRMT6,ESR2A,NR0B2A,DDOST |
Protein Function
APEH has several biochemical functions, for example, omega peptidase activity,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APEH itself. We selected most functions APEH had, and list some proteins which have the same functions with APEH. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| omega peptidase activity | UCHL5,ATXN3,ATXN3L,UCHL1,GGH,JOSD1,USP13,USP5,JOSD2 |
| poly(A) RNA binding | EIF4A3,SYNCRIP,MAK16,METTL16,DBR1,ZCCHC17,DDX17,DHX9,CD3EAP,LUC7L2 |
| serine-type endopeptidase activity | AZU1,C1rb,PLAT,PRSS38,TPP2,PREP,HTRA2,C1S,TMPRSS5,PRSS58 |
| protein binding | GINS2,DCBLD2,ACAT2,TLR13,LRRC6,ALDH7A1,RBMY1A1,ATP6V1D,TOPORS,KIAA1737 |
Interacting Protein
APEH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APEH here. Most of them are supplied by our site. Hope this information will be useful for your research of APEH.
IST1;LGALS8;MCC;HLA-B;TMEM62;UBA5;15-deoxy-delta(12,14
Resources
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References
- Perrier, J; Durand, A; et al. Catabolism of intracellular N-terminal acetylated proteins: involvement of acylpeptide hydrolase and acylase. BIOCHIMIE 87:673-685(2005).
- Chongcharoen, K; Sharma, KK; et al. Characterization of trypsin-modified bovine lens acylpeptide hydrolase. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 247:136-141(1998).
